In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin

Proteins: Structure, Function and Genetics

Volumn 71, Issue 1, 2008, Pages 24-34

  Cherezov, Vadim ^a,f   Liu, Wei ^a,b   Derrick, Jeremy P ^c   Luan, Binquan ^d   Aksimentiev, Aleksei ^d   Katritch, Vsevolod ^e   Caffrey, Martin ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF LIMERICK   (Ireland)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d University of Illinois at Urbana Champaign   (United States)

^e MOLSOFT LLC   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Lipidic cubic phase; Membrane protein crystallization; Molecular dynamics; Sialic acid; X ray diffraction

Indexed keywords

ADHESIN; OPCA PROTEIN; OUTER MEMBRANE PROTEIN; POLYSACCHARIDE; PROTEOGLYCAN; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; BACTERIAL OUTER MEMBRANE; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; LIGAND BINDING; LIPID BILAYER; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NEISSERIA MENINGITIDIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIMULATION; STRUCTURE ANALYSIS;

ADHESINS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NEISSERIA MENINGITIDIS; PROTEIN BINDING; PROTEOGLYCANS; SPECTRUM ANALYSIS;

NEISSERIA MENINGITIDIS;

EID: 40549083360     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21841     Document Type: Article

References (46)