A search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction

International Journal of Immunogenetics

Volumn 35, Issue 2, 2008, Pages 159-164

  Palacin M ^a   Rodriguez I ^a   Garcia Castro M ^a   Ortega, F ^a,b   Reguero, J R ^a   Lopez Larrea C ^a,b   Moris C ^a   Alvarez, V ^a   Coto, E ^a,b  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b Instituto de Investigación Nefrológica Fundación Renal I   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN A; DNA; LUCIFERASE;

5' UNTRANSLATED REGION; ADULT; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PLASMID; POLYMERASE CHAIN REACTION; PPIA GENE; PRIORITY JOURNAL; PROMOTER REGION; SMOKING;

ADULT; ALLELES; CORONARY ARTERY DISEASE; CYCLOPHILIN A; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); RISK FACTORS;

EID: 40449136153     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/j.1744-313X.2008.00755.x     Document Type: Article

References (36)

1. An, P., Wang, L.H., Hutcheson-Dilks, H., Nelson, G., Donfield, S., Goedert, J.J. et al 2007) Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. PLoS Pathogens, 3, e88.
2. 2- in vascular smooth muscle cells. Circulation Research, 77, 29.
3. Berk, B.C. (2001) Vascular smooth muscle growth: autocrine growth mechanisms. Physiological Reviews, 81, 999.
4. Billich, A., Winkler, G., Aschauer, H., Rot, A. Peichl, P. (1997) Presence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis. Journal of Experimental Medicine, 185, 975.
5. Bleiber, G., May, M., Martinez, R., Meylan, P., Ott, J., Beckmann, J., Telenti, A., the Swiss HIV Cohort Study (2005) Use of a combined ex vivo/in vivo population approach for screening of human genes involved in the human immunodeficiency virus type 1 life cycle for variants influencing disease progression. Journal of Virology, 79, 12674.
6. Cambien, F. (2005) Coronary heart disease and polymorphisms in genes affecting lipid metabolism and inflammation. Current Atherosclerosis Reports, 7, 188.
7. Chen, S., Zhang, M., Ma, H., Saiyin, H., Shen, S., Xi, J., Wan, B. Yu, L. (2008) Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance. Cancer Chemotherapy and Pharmacology, 61, 459.
8. Colgan, J., Asmal, M., Yu, B. Luban, J. (2005) Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. Journal of Immunology, 174, 6030.
9. Coppinger, J.A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J.P. et al 2004) Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103, 2096.
10. Doyle, V., Virji, S. Crompton, M. (1999) Evidence that cyclophilin-A protects cells against oxidative stress. Biochemical Journal, 341, 127.
11. Franke, E.K., Yuan, H.E., Bossolt, K.L., Goff, S.P. Luban, J. (1994) Specificity and sequence requirements for interactions between various retroviral Gag proteins. Journal of Virology, 68, 5300.
12. García-Castro, M., Reguero, J.R., Batalla, A., Díaz-Molina, B., González, P., Alvarez, V., Cortina, A., Cubero, G.I. Coto, E. (2003) Hypertrophic cardiomyopathy: low frequency of mutations in the beta-myosin heavy chain and cardiac troponin T genes among Spanish patients. Clinical Chemistry, 49, 1279.
13. González, P., Álvarez, R., Batalla, A., Reguero, J.R., Alvarez, V., Astudillo, A., Cubero, G.I., Cortina, A. Coto, E. (2001) Genetic variation at the chemokines receptors CCR5/CCR2 in myocardial infarction. Genes and Immunity, 2, 191.
14. Jin, Z.G. Berk, B.C. (2001) Signal transduction cascades responsive to oxidative stress in the vasculature. Protein Adaptation and Signal Transduction, 18, 239.
15. Jin, Z.G. Berk, B.C. (2004) Role of secreted oxidative stress-induced factors (SOXFs) in the pathogenesis of atherosclerosis. Archives des Maladies du Coeur et des Vaisseaux, 97, 1256.
16. Jin, Z.G., Melaragno, M.G., Liao, D.F., Yan, C., Haendeler, J., Suh, Y.A., Lambeth, J.D. Berk, B.C. (2000) Cyclophilin A is a secreted growth factor induced by oxidative stress. Circulation Research, 87, 789.
17. Jin, Z.G., Lungu, A.O., Xie, L., Wang, M., Wong, C. Berk, B.C. (2004) Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1186.
18. Kim, S.H., Lessner, S.M., Sakurai, Y. Galis, Z.S. (2004) Cyclophilin A as a novel biphasic mediator of endothelial activation and dysfunction. American Journal of Pathology, 164, 1567.
19. Kim, H., Kim, W.J., Jeon, S.T., Koh, E.M., Cha, H.S., Ahn, K.S. Lee, W.H. (2005) Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages. Clinical Immunology, 116, 217.
20. Lamas, S. (2005) Cellular mechanisms of vascular injury mediated by calcineurin inhibitors. Kidney International, 68, 898.
21. Luban, J., Bossolt, K.L., Franke, E.K., Kalpana, G.V. Goff, S.P. (1993) Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell, 73, 1067.
22. Lusis, A.J. (2000) Atherosclerosis. Nature, 407, 233.
23. Marks, A.R. (1996) Cellular functions of immunophilins. Physiology Reviews, 76, 631.
24. Miller, S.A., Dykes, D.D. Polesky, H.F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research, 16, 1215.
25. Orita, M., Iwahana, H., Kanazawa, H., Hayashi, K. Sekiya, T. (1989) Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation analysis. Proceedings of the National Academy of Sciences, USA, 86, 2766.
26. Rao, G.N. Berk, B.C. (1992) Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogen expression. Circulation Research, 70, 593.
27. Rodriguez, I., Coto, E., Reguero, J., González, P., Andrés, V., Lozano, I., Martín, M., Alvarez, V. Morís, C. (2007) Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction. Cell Cycle, 6, 620.
28. Saphire, A.C., Bobardt, M.D. Gallay, P.A. (2002) Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation. Journal of Virology, 76, 4671.
29. Suzuki, J., Jin, Z.G., Meoli, D.F., Matoba, T. Berk, B.C. (2006) Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circulation Research, 98, 811.
30. Topol, E.J., Smith, J., Plow, E.F. Wang, Q.K. (2006) Genetic susceptibility to myocardial infarction and coronary artery disease. Human Molecular Genetics, 15, R11.
31. Trogan, E., Choudhury, R.P., Dansky, H.M., Rong, J.X., Breslow, J.L. Fisher, E.A. (2002) Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice. Proceedings of the National Academy of Sciences, USA, 99, 2234.
32. Wang, Q. (2005) Advances in the genetics basis of coronary artery disease. Current Atherosclerosis Reports, 7, 235.
33. Wang, P. Heitman, J. (2005) The cyclophilins. Genome Biology, 6, 226.
34. Yang, H., Li, M., Chai, H., Yan, S., Lin, P., Lumsden, A.B., Yao, Q. Chen, C. (2005) Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. Journal of Surgical Research, 123, 312.
35. Zander, K., Sherman, M.P., Tessmer, U., Bruns, K., Wray, V., Prechtel, A.T. et al 2003) Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression. Journal of Biological Chemistry, 278, 43202.
36. Zheng-General, J., Lungu, A.O., Xie, L., Wang, M., Wong, C. Berk, B.C. (2004) Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1186.