EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR

Biochemical Journal

Volumn 410, Issue 2, 2008, Pages 309-317

  Molle, Virginie ^a   Reynolds, Robert C ^b   Alderwick, Luke J ^c   Besra, Gurdyal S ^c   Cozzoime, Alain J ^a   Fütterer, Klaus ^c   Kremer, Laurent ^d,e  

^a UNIVERSITÉ LYON 1   (France)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d CNRS   (France)

^e UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

EmbR; Forkhead associated domain (FHA domain); Mycobacterium; PknH; Serine threonine protein kinase; Structural model

Indexed keywords

ARABINOSYLTRANSFERASES; AUTOKINASE ACTIVITY; TUBERCULOSIS;

BINDING SITES; DNA; GENE ENCODING; PHOSPHORYLATION; TRANSCRIPTION;

ENZYME ACTIVITY;

CYCLIN DEPENDENT KINASE; GENE PRODUCT; GUANINE DERIVATIVE; PHOSPHOPEPTIDE; PROTEIN PKNE; PROTEIN PKNF; PROTEIN PKNH; PROTEIN SERINE THREONINE KINASE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EMBR; TRANSCRIPTION FACTOR EMBR2; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; EUKARYOTE; FLUORESCENCE; GENOMICS; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; STRUCTURAL HOMOLOGY;

BACTERIAL PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, BACTERIAL; KINETICS; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PHOSPHOAMINO ACIDS; PHOSPHOPEPTIDES; PHOSPHORYLATION; POLYSACCHARIDES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS;

EUKARYOTA; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 40449124718     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071384     Document Type: Article

References (46)