Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery

Eye and Contact Lens

Volumn 34, Issue 2, 2008, Pages 129-130

  Di Pascuale, Mario A ^a   Whitson, Jess T ^a,b   Mootha, V Vinod ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PFIZER

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ARTIFICIAL TEAR; DICLOFENAC; DORZOLAMIDE PLUS TIMOLOL; MOXIFLOXACIN; NEPAFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; POLYSPORIN; TRAVOPROST;

AGED; ANAMNESIS; ARTICLE; CASE REPORT; CATARACT EXTRACTION; CLINICAL FEATURE; CORNEA DISEASE; CORNEA ULCER; DRUG WITHDRAWAL; FEMALE; HUMAN; HUMAN CELL; INTRAOCULAR PRESSURE; PRIORITY JOURNAL; RETINA MACULA CYSTOID EDEMA; VISUAL ACUITY;

AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZENEACETAMIDES; CORNEAL DISEASES; FEMALE; HUMANS; MACULAR EDEMA; PHENYLACETATES; VISUAL ACUITY;

EID: 40449096113     PISSN: 15422321     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICL.0b013e31814510a8     Document Type: Article

References (5)

1. Shimazaki J, Saito H, Yang HY, et al. Persistent epithelial defect following penetrating keratoplasty: An adverse effect of diclofenac eyedrops. Cornea 1995;14:623-627.
2. Hargrave SL, Jung JC, Fini ME, et al. Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: An analysis of postoperative keratolysis. Ophthalmology 2002;109:343-350.
3. Ke TL, Graff G, Spellman JM, et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation 2000;24:371-384.
4. Lindstrom R, Kim T. Ocular permeation and inhibition of retinal inflammation: An examination of data and expert opinion on the clinical utility of nepafenac. Curr Med Res Opin 2006;22:397-404.
5. O'Brien TP, Li QJ, Sauerburger F, et al. The role of matrix metalloproteinases in ulcerative keratolysis associated with perioperative diclofenac use. Ophthalmology 2001;108:656-659.