메뉴 건너뛰기




Volumn 6, Issue 23, 2007, Pages

Inhibitory effects of thymoquinone, the major component of Nigella sativa L. seeds, on spontaneous and evoked contractions of guinea pig isolated ileum

Author keywords

Calcium channels; Guinea pig ileum; Tension recording; Thymoquinone

Indexed keywords

ACETYLCHOLINE; CALCIUM CHANNEL; CALCIUM CHLORIDE; HISTAMINE; NIGELLA SATIVA EXTRACT; POTASSIUM CHLORIDE; THYMOQUINONE;

EID: 40449091206     PISSN: 2717204X     EISSN: 27172058     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (37)
  • 1
    • 85171716376 scopus 로고    scopus 로고
    • Ali BH and Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. 2003; 17: 299-305.
  • 2
    • 85171708873 scopus 로고    scopus 로고
    • Aqel-Mahmoud B. The relaxing effects of the volatile oil of Nigella sativa seeds on vascular smooth muscle. Dirasat Series B. Pure Appl. Sci. 1993; 19: 91-100.
  • 3
    • 85171708896 scopus 로고    scopus 로고
    • El-Tahir KEH, Al-Tahir AY, and Ageel AM. Pharmacological studies on sesame and Nigella sativa fixed oil: Effects on the sensitivities of the adrenoceptors, baroreceprors, platelets and the uterus of the rat. Saudi. Pharmac. J. 1997; 7: 205-215.
  • 4
    • 85171723358 scopus 로고    scopus 로고
    • El-Tahir KEH, Ashour MMS, and Al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: Elucidation of the mechanism of action. Gen. Pharmacol. 1993; 24: 1123-1131.
  • 5
    • 85171721131 scopus 로고    scopus 로고
    • Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, and Hassar M. Diuretic and hypotensive effects of Nigella sativa on the spontaneously hypertensive rat. Therapie 2000; 55: 379-382.
  • 6
    • 85171709052 scopus 로고    scopus 로고
    • Aqel-Mahmoud B. Effects of Nigella sativa seeds on intestinal smooth muscle. Int. J. Pharmacol. 1993; 31: 55-60.
  • 7
    • 85171701218 scopus 로고    scopus 로고
    • Gilani AH, Aziz N, and Khurram M. Bronchodilator, Spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. J. Pak. Med. Assoc. 2001; 51: 115-120.
  • 8
    • 85171720170 scopus 로고    scopus 로고
    • Aqel-Mahmoud B. The calcium antagonistic effect of the volatile oil of Nigella sativa seeds. Dirasat Series B. Pure Appl. Sci. 1993; 19: 119-133.
  • 9
    • 85171703214 scopus 로고    scopus 로고
    • Boskabady MH, and Shahabi M. Bronchodilatory and anticholinergic effects of Nigella sativa on isolated guinea pig tracheal chains. Ir. J. Med. Sci. 1997; 22: 127-133.
  • 10
    • 85171711196 scopus 로고    scopus 로고
    • Boskabady MH and Sheiravi N. Inhibitory effects of Nigella sativa on histamine (H1) receptors of isolated guinea pig tracheal chains. Pharmac. Biol. 2002; 40: 596-602.
  • 11
    • 85171718846 scopus 로고    scopus 로고
    • Boskabady MH, Shirmohammadi B, Jandaghi P and Kiani S. Possible mechanism (s) for relaxant effects of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. BMC Pharmacol. 2004; 4: 3.
  • 12
    • 85171718205 scopus 로고    scopus 로고
    • Aqel M and Shaheen R. Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. J. Ethnopharmacol. 1996; 52: 23-26.
  • 13
    • 85171722657 scopus 로고    scopus 로고
    • Filippo D'Antuono L, Moretti A, and Lovato AFS. Seed yield, yield components, oil content and essential oil content and composition of Nigella sativa L. and Nigella damascena L. Indust. Crops. Prod. 2002; 15: 59-69.
  • 14
    • 85171707168 scopus 로고    scopus 로고
    • Parvardeh S and Hosseinzadeh H. Hypnosis and muscular relaxant activity of thymoquinet of Nigella sativa seeds and its effect on locomotion and coordination in mice. Medicinal Plants 2003; 2, 17-25.
  • 15
    • 85171717953 scopus 로고    scopus 로고
    • Parvardeh S, Nasiri Asl M, Hossinzadeh H. Protective effects of thymoquinone against ischemia-reperfusion injury in rat brain. Iranian Journal of Basic Medical Sciences 2004; 7: 65-70.
  • 16
    • 85171702408 scopus 로고    scopus 로고
    • Parvardeh S and Hosseinzadeh H. Role of opioid receptors on anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa, in mice. Iranian Journal of Basic Medical Sciences 2003; 6: 202-206.
  • 17
    • 85171701058 scopus 로고    scopus 로고
    • Hosseinzadeh H, and Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine 2004; 11: 56-64.
  • 18
    • 85171722113 scopus 로고    scopus 로고
    • Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, and Mansouri MT. Intra-cerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med. Sci. Monit. 2005; 11, 106-110.
  • 19
    • 85171708058 scopus 로고    scopus 로고
    • Abdel-Fattah AM, Matsumoto K, and Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur. J. Pharmacol. 2000; 400: 89-97.
  • 20
    • 85171709644 scopus 로고    scopus 로고
    • Houghton PI, Zarka R, Delas Heras B and Hoult RS. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995; 61: 33-36.
  • 21
    • 85171727814 scopus 로고    scopus 로고
    • Badary OA. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J. Ethnopharmacol. 1999; 67: 135-142.
  • 22
    • 85171707595 scopus 로고    scopus 로고
    • Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N and Crooks PA. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 2004; 15: 389-399.
  • 23
    • 85171713413 scopus 로고    scopus 로고
    • Hassan M and El-Dakhakhny M. Effect of some Nigella sativa Constituents on chemical carcinogenesis in hamster cheek pouch. J. Egypt. Soci. Pharmacol. Exp. Ther. 1992; 11: 675-677.
  • 24
    • 85171726177 scopus 로고    scopus 로고
    • Worthen DR, Ghosheh OA and Crooks PA. The in vitro anti-tumor activity of some crude and purified components of black seed, Nigella sativa L. Anticancer Res. 1998; 18 (3 A): 1527-1532.
  • 25
    • 85171724960 scopus 로고    scopus 로고
    • Al-Gharably NM, Badary OA, Nagi MN, Al-Shabanah OA, Al-Sawaf HA, Al-Rikabi AC. Protective effect of thymoquinone against carbon tetrachloride-induced hepatotoxicity in mice. Res. Commun. Pharmacol. Toxicol. 1997; 2: 41-50.
  • 26
    • 85171703511 scopus 로고    scopus 로고
    • Daba MH and Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rathepatocytes. Toxicol. Lett. 1998; 95: 23-9.
  • 27
    • 85171724643 scopus 로고    scopus 로고
    • Nagi MN, Alam K, Badary OA, al-Shabanah OA, al-Sawaf HA and Al-Bekairi AM. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem. Mol. Biol. Int. 1999; 47: 153-159.
  • 28
    • 85171724927 scopus 로고    scopus 로고
    • Badary OA, Nagi MN, Al-Shabanah OA, Al-Sawaf HA, Al-Sohaibani MO and Al-Bekairi AM. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can. J. Physiol. Pharmacol. 1997; 75: 1356-1361.
  • 29
    • 85171719174 scopus 로고    scopus 로고
    • Al-Majed AA, Daba MH, Asiri YA, Al-Shabanah OA, Mostafa AA and El-Kashef HA. Thymoquinone-induced relaxation of guinea-pig isolated trachea. Res. Commun. Mol. Pathol. Pharmacol. 2001; 110: 333-345.
  • 30
    • 85171702086 scopus 로고    scopus 로고
    • Daniel EE, Kwan CY and Janssen L. Pharmacological techniques for the in vitro study of intestinal smooth muscles. J. Pharmacol. Toxicol. Meth. 2000; 45: 141-158.
  • 31
    • 85171710431 scopus 로고    scopus 로고
    • Eglen RM, Reddy H, Watson N and Chalks RAJ. Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev. 1996; 48: 531-565.
  • 32
    • 85171721461 scopus 로고    scopus 로고
    • Bolton TB. Mechanism of action of transmitters and other substances on smooth muscle. Physiol. Rev. 1979; 59: 606-718.
  • 33
    • 85171726508 scopus 로고    scopus 로고
    • Godfraind T, Miller R and Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev. 1986; 38: 321-416.
  • 34
    • 85171718745 scopus 로고    scopus 로고
    • Scherkl R, Hashem A and Frey HH. Histamine in brain: its role in regulation of seizure susceptibility. Epilepsy Res. 1991; 10: 111-118.
  • 35
    • 85171725259 scopus 로고    scopus 로고
    • Yokoyama H, Onodera K, Iinuma K and Watanabe T. 2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice. Pharmacol. Biochem. Behav. 1994; 47: 503-507.
  • 36
    • 85171707411 scopus 로고    scopus 로고
    • Yokoyama H, Onodera K, Maeyama K, Yanai K, Iinuna K, Tuomisto L and Watanabe T. Histamine levels and clonic convulsions of electrically-induced seizures in mice. Naunyn Schmiedeberg's Arch. Pharmacol. 1992; 346: 40-45.
  • 37
    • 85171727549 scopus 로고    scopus 로고
    • Horowitz B, Ward SM and Sanders KM. Cellular and molecular basis for electrical rhythmicity in gastrointestinal muscles. Annu. Rev. Physiol. 1999; 61: 19-43.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.