Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability

Journal of Biochemical and Molecular Toxicology

Volumn 18, Issue 3, 2004, Pages 162-169

  Fernandes, Maria A S ^a   Santos, Maria S ^a   Moreno, António J M ^a   Duburs, Gunars ^b   Oliveira, Catarina R ^c   Vicente, Joaquim A F ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

1,4 dihydropyridine derivatives; Antidiabetics; Bioenergetics; Cerebocrast; Glibenclamide; Mitochondria; Sulphonylureas; Toxicity; Type 2 diabetes

Indexed keywords

ACETIC ACID; ANION CHANNEL; CHLORIDE ION; GLIBENCLAMIDE; POTASSIUM CHLORIDE; POTASSIUM ION; POTASSIUM NITRATE; PROTON; SULFONYLUREA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CHANNEL GATING; CHLORIDE TRANSPORT; CONTROLLED STUDY; CULTURE MEDIUM; ION PERMEABILITY; LIVER MITOCHONDRION; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; NONHUMAN; OSMOSIS; POTASSIUM TRANSPORT; RAT;

ANIMALS; CELL MEMBRANE PERMEABILITY; CELL RESPIRATION; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; GLYBURIDE; HYPOGLYCEMIC AGENTS; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXYGEN CONSUMPTION; POTASSIUM; PROTONS; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE;

EID: 4043179966     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20022     Document Type: Article

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