Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes

Journal of Biochemical and Molecular Toxicology

Volumn 18, Issue 3, 2004, Pages 131-132

  Jin, Bohwan ^a   Ryu, Doug Young ^a  

^a Seoul National University   (South Korea)

Author keywords

CYP1A2; Hepatocytes; Histone deacetylase inhibitor; Mouse

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BUTYRIC ACID; CYTOCHROME P450 1A2; HISTONE; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN A;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME REGULATION; GENE SILENCING; INHIBITION KINETICS; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; TIME;

ANIMALS; BUTYRATES; CYTOCHROME P-450 CYP1A2; DRUG INTERACTIONS; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; ENZYME REPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; KINETICS; MICE; TETRACHLORODIBENZODIOXIN;

EID: 4043121955     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20017     Document Type: Article

References (4)

1. Quattrochi LC, Vu T, Tukey RH. The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction. J Biol Chem 1994;269:6949-6954.
2. Ryu DY, Levi PE, Fernandez-Salguero P, Gonzalez FJ, Hodgson E. Piperonyl butoxide and acenaphthylene induce cytochrome P450 1A2 and 1B1 mRNA in aromatic hydrocarbon-responsive receptor knock-out mouse liver. Mol Pharmacol 1996;50:443-446.
3. Schuetz EG, Li D, Omiecinski CJ, Muller-Eberhard U, Kleinman HK, Elswick B, Guzelian PS. Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol 1988;134: 309-323.
4. Jaenisch R, Bird A. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet 2003;33(Suppl):245-254.