Expression of cell cycle related proteins in a rapidly growing uveal malignant melanoma

Retina

Volumn 24, Issue 4, 2004, Pages 646-649

  Honda, Shigeru ^a   Hirai, Tatsuya ^a   Handa, James T ^b   Okuno, Tomoko ^a   Saito, Isao ^a  

^a Kitano Hospital   (Japan)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Immunohistochemistry; p53; pRb; Rapid growth; Uveal melanoma

Indexed keywords

CELL CYCLE PROTEIN; PROTEIN BCL 2; PROTEIN HMB45; PROTEIN P16; PROTEIN P53; PROTEIN S 100; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

AGED; ARTICLE; CANCER GRADING; CANCER GROWTH; CASE REPORT; CHOROID; CLINICAL EXAMINATION; CLINICAL FEATURE; DIAGNOSTIC VALUE; ENUCLEATION; EVALUATION; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; JAPAN; MALIGNANT NEOPLASTIC DISEASE; PROTEIN EXPRESSION; RETINA CELL; SPINDLE CELL; STAINING; TUMOR GROWTH; UVEA MELANOMA;

AGED; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EYE ENUCLEATION; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; IMMUNOENZYME TECHNIQUES; MELANOMA; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINOBLASTOMA PROTEIN; S100 PROTEINS; TUMOR MARKERS, BIOLOGICAL; UVEAL NEOPLASMS;

EID: 4043116418     PISSN: 0275004X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006982-200408000-00030     Document Type: Article

References (10)

1. Kincaid MC. Uveal melanoma. Cancer Control 1998;5:299-309.
2. Augsburger JJ, Gonder JR, Amsel J, Shields JA, Donoso LA. Growth rates and doubling times of posterior uveal melanomas. Ophthalmology 1984;91:1709-1715.
3. Gass JDM. Comparison of uveal melanoma growth rates with mitotic index and mortality. Arch Ophthalmol 1985;103: 924-931.
4. Laquis SJ, Freeman JM, Fleming JC, Wilson MW, Haik BG. A rapidly growing choroidal melanoma. Am J Ophthalmol 2002;133:580-581.
5. Brantley MA Jr, Harbour JW. Deregulation of the Rb and p53 pathways in uveal melanoma. Am J Pathol 2000;157:1795-1801.
6. Chana JS, Wilson GD, Cree IA, et al. c-myc, p53, and Bcl-2 expression and clinical outcome in uveal melanoma. Br J Ophthalmol 1999;83:110-114.
7. Korabiowska M, Ruschenburg I, Betke H, et al. Downregulation of the retinoblastoma gene expression in the progression of malignant melanoma. Pathobiology 2001;69:274-280.
8. Massaro-Giordano M, Baldi G, De Luca A, Baldi A, Giordano A. Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance. Clin Cancer Res 1999;5:1455-1458.
9. Tobal K, Warren W, Cooper CS, McCartney A, Hungerford J, Lightman S. Increased expression and mutation of p53 in choroidal melanoma. Br J Cancer 1992;66:900-904.
10. Steel GG. Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer. Oxford, UK: Clarendon Press, 1977:5-55.