Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats

Acta Pharmacologica Sinica

Volumn 25, Issue 8, 2004, Pages 996-999

  Shi, Jing Min ^a,b   Lai, Shun Guo ^a   Xu, Chang Jiang ^a   Duan, Geng Li ^a   Li, Duan ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

Etodolac; Non steroidal anti inflammatory agents; Pharmacokinetics; Stereoisomerism

Indexed keywords

ETODOLAC;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PARAMETER; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ETODOLAC; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 4043094778     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Evans AM. Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs. Eur J Clin Pharmacol 1992; 42: 237-56.
2. Demerson CA, Humber LG, Abraham NA, Schilling G, Martel RR, Pace-Asciak C, et al. Resolution of etodolac and anti-inflammatory and prostaglandin synthetase inhibiting properties of the enantiomers. J Med Chem 1983; 26: 1778-80.
3. Shi JM, Li D. Etodolac, new chiral nonsteroidal anti-inflammatory drug. Chin J Clin Pharm 2000; 9: 321-4.
4. Humber LG. Etodolac: the chemistry, pharmacology, metabolic disposition, and clinical profile of a novel anti-inflammatory pyranocarboxylic acid. Med Res Rev 1987; 7: 1-28.
5. Jamali F, Mehvar R, Lemko C, Eradiri O. Application of a stereospecific high-performance liquid chromatography assay to a pharmacokinetic study of etodolac enantiomers in humans. J Pharm Sci 1988; 77: 963-6.
6. Brocks DR, Jamali F. The pharmacokinetics of etodolac enantiomers in the rat: lack of pharmacokinetic interaction between enantiomers. Drug Metab Dispos 1990; 18: 471-5.
7. Shi JM, Xu ChJ, Duan GL, Li D. High performance liquid chromatography method determination of etodolac and study of its pharmacokinetics in rats. Chin J New Drugs Clin Rem 2002; 21: 193-6.
8. Brocks DR, Jamali F. Enantioselective pharmacokinetics of etodolac in the rat: tissue distribution, tissue binding, and in vitro metabolism. J Pharm Sci 1991; 80: 1058-61.
9. Brocks DR, Jamali F, Russell AS, Skeith KJ. The stereoselective pharmacokinetics of etodolac in young and elderly subjects and after cholecystectomy. J Clin Pharmacol 1992; 32: 982-9.
10. Jamali F. Pharmacokinetics of enantiomers of chiral nonsteroidal anti-inflammatory drugs. Eur J Drug Metab Pharmacokinet 1988; 13: 1-9.
11. Brocks DR, Jamali F, Russell AS. Stereoselective disposition of etodolac enantiomers in synovial fluid. J Clin Pharmacol 1991; 31: 741-6.
12. Muller N, Lapicque F, Monot C, Payan E, Dropsy R, Netter P. Stereoselective binding of etodolac to human serum albumin. Chirality 1992; 4: 240-6.
13. Ferdinandi ES, Cochran D, Gedamke R. Identification of the etodolac metabolite, 4-ureidoetodolac, in mouse, rat, dog, and man. Drug Metab Dispos 1987; 15: 921-4.