Gemcitabine plus vinorelbine chemotherapy regimens: A pharmacokinetic study of alternate administration sequences

Pharmacy World and Science

Volumn 26, Issue 4, 2004, Pages 238-241

  Cattel, Luigi ^a   Airoldi, Mario ^b   Passera, Roberto ^a   Cagliero, Elga ^c   Stella, Barbara ^a   Goffredo, Franca ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c Servizio di Farmacia   (Italy)

Author keywords

Breast cancer; Chemotherapy; Gemcitabine; Head neck cancer; Hodgkin's lymphoma; HPLC analysis; Non small cell lung cancer; Pharmacokinetics; Vinorelbine

Indexed keywords

GEMCITABINE; NAVELBINE;

AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CARCINOMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROL GROUP; DRUG BLOOD LEVEL; HEAD CANCER; HODGKIN DISEASE; HUMAN; LUNG NON SMALL CELL CANCER; MONOTHERAPY; NECK CANCER; PHARMACEUTICAL CARE; PLASMA CLEARANCE; STATISTICAL SIGNIFICANCE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AREA UNDER CURVE; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; DEOXYCYTIDINE; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; FORECASTING; HALF-LIFE; HEAD AND NECK NEOPLASMS; HUMANS; INFUSIONS, INTRAVENOUS; ITALY; KINETICS; LYMPHOMA, NON-HODGKIN; VINBLASTINE;

EID: 4043080031     PISSN: 09281231     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAR.0000035884.89280.8c     Document Type: Article

References (10)

1. Storniolo AM, Allerheiligen S, Pearce HL. Preclinical, pharmacologic and phase I studies of gemcitabine. Semin Oncol 1997; 24: 2-7.
2. Eli Lilly and Co. Summary of product characteristics: gemcitabine. UK prescribing information. Eli Lilly 1997.
3. Gregory RK, Smith IE. Vinorelbine: a clinical review. Br J Cancer 2000; 82: 1907-13.
4. Rahmani R, Bruno R, Iliadis A et al. Clinical pharmacokinetics of the antitumor drug navelbine. Cancer Res 1987; 47: 5796-9
5. Chen YM, Peng JW, Perng RP et al. A multicenter phase II study of gemcitabine and vinorelbine in patients with advanced stage IIIB/IV non-small cell lung cancer. Proc Am Soc Clin Oncol 1999; 18: 481 (Abstract).
6. Cattel L, Recalenda V, Airoldi M et al. A sequence-dependent combination of docetaxel and vinorelbine: pharmacokinetic interactions. Farmaco 2001; 56: 779-84.
7. Freeman KB, Anliker S, Hamilton M et al. Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B 1995; 665: 171-81.
8. Robieux I, Vitali V, Aita P et al. Sensitive high-performance liquid chromatographic method with fluorescence detection for measurement of vinorelbine plasma concentration. J Chromatogr B 1996; 675: 183-7.
9. Perez-Manga G, Lluch A, Alba E et al. Gemcitabine in combination with doxorubicin in advanced breast cancer: final results of a phase II pharmacokinetic trial. J Clin Oncol 2000; 18: 2545-52.
10. Sorio R, Robieux I, Galligioni E et al. Pharmacokinetics and tolerance of vinorelbine in elderly patients with metastatic breast cancer. Eur J Cancer 1997; 33: 301-3.