Metabolism of 1-{3-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-propyl}-3-(6- methoxypyridin-3-yl)-1-(2-trifluoromethylbenzyl)thiourea (YH3945), a novel anti-cancer drug, in rats using the 14C-labeled compound

Rapid Communications in Mass Spectrometry

Volumn 18, Issue 17, 2004, Pages 1901-1910

  Lee, Jaeick ^a   La, Sookie ^a   Ahn, Byung Rak ^b   Jeong, Tae Cheon ^c   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Yuhan Research Institute   (South Korea)

^c Yeungnam University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CHEMICAL STABILITY; DISEASES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHYSIOLOGY; RADIOACTIVITY; SPECTRUM ANALYSIS; THIOUREAS;

ANTI-CANCER AGENTS; ANTICANCER DRUG; BILIARY EXCRETION; GLUCURONIDE CONJUGATES; HEPATOBILIARY EXCRETION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; IMIDAZOL; LIQUID CHROMATOGRAPHY SYSTEM; NON-ENZYMATIC; SPECTRAL ANALYZE;

RATS;

1 [3 [3 (4 CYANOBENZYL) 3H IMIDAZOL 4 YL]PROPYL] 3 (6 METHOXYPYRIDIN 3 YL) 1 (2 TRIFLUOROMETHYLBENZYL)THIOUREA; ANTINEOPLASTIC AGENT; CARBON 14; DRUG METABOLITE; IMIDAZOLE; O DEMETHYLASE; UNCLASSIFIED DRUG; YH 3945;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; CYCLIZATION; DEBENZYLATION; DEMETHYLATION; DEVICE; DOSE RESPONSE; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; FECES ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RADIATION DETECTION; RAT; REACTION ANALYSIS; ULTRAVIOLET RADIATION; URINALYSIS;

EID: 4043055079     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1555     Document Type: Article

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