The ethical justification for minor sibling bone marrow donation: A case study

Oncologist

Volumn 13, Issue 2, 2008, Pages 148-151

  Pentz, Rebecca D ^a   Haight, Ann E ^b   Noll, Robert B ^c   Barfield, Raymond ^d   Pelletier, Wendy ^e   Davies, Stella ^f   Alderfer, Melissa A ^g   Hinds, Pamela S ^d  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e ALBERTA CHILDREN'S HOSPITAL   (Canada)

^f CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^g CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

ADOLESCENT; ARTICLE; BONE MARROW; CASE REPORT; DONOR SELECTION; FAMILY DECISION MAKING; HLA SYSTEM; HUMAN; INTIMACY; JUVENILE; LEUKEMIA; MALE; MEDICAL ETHICS; MENTAL DEFICIENCY; NOCICEPTION; ONCOLOGY; ORGAN DONOR; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SIBLING RELATION; STEM CELL TRANSPLANTATION; SURVIVAL;

ADOLESCENT; BONE MARROW TRANSPLANTATION; ETHICS, MEDICAL; HUMANS; LEUKEMIA; MALE; MENTAL RETARDATION; MINORS; SIBLINGS;

EID: 40349103529     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2007-0185     Document Type: Article

References (31)

1. Wall D. Letter to Eric Kodish E, Chair, Children's Oncology Group Bioethics Committee, February 8, 2005.
2. Curran WJ. Beyond the best interests of a child. Bone marrow transplantation among half-siblings. N Engl J Med 1991;324:1818-1819.
3. Williams TE. Legal issues and ethical dilemmas surrounding bone marrow transplantation in children. Am J Pediatr Hematol Oncol 1984;6:83-88.
4. Burgio GR, Locatelli F, Nespoli L. Hematopoietic stem cell transplantation in pediatric practice: A bioethical assessment. In: Burgio GR, Lantos JD, eds. Primum Non Nocere Today. New York: Elsevier, 1998:85-99.
5. Month S. Preventing children from donating may not be in their best interests. BMJ 1996;312:240-241.
6. MacLeod KD, Whitsett SF, Mash EJ et al. Pediatric sibling donors of successful and unsuccessful hematopoietic stem cell transplants (HSCT): A qualitative study of their psychosocial experience. J Pediatr Psychol 2003;28:223-230.
7. Switzer GE, Dew MA, Twillman RK. Psychosocial issues in living organ donation. In: Trzepacz PT, DiMartini AF, eds. The Transplant Patient: Biological, Psychiatric, and Ethical Issues in Organ Transplantation. Cambridge, UK: Cambridge University Press, 2000:42-66.
8. Switzer GE, Dew MA, Magistro CA et al. The effects of bereavement on adult sibling bone marrow donors' psychological well-being and reactions to donation. Bone Marrow Transplant 1998;21:181-188.
9. Packman W, Crittenden M, Fischer JBR et al. Siblings' Perceptions of the Bone Marrow Transplantation Process. J Psychosoc Oncol 1997;15:81-105.
10. Packman WL, Crittenden MR, Schaeffer E et al. Psychosocial consequences of bone marrow transplantation in donor and nondonor siblings. J Dev Behav Pediatr 1997;18:244-253.
11. Packman W, Beck V, VanZutphen K et al. The human figure drawing with donor and nondonor siblings of pediatric bone marrow transplant patients. Art Ther 2003;20:83-91.
12. Snethen JA, Broome ME. Children in research: The experiences of siblings in research is a family affair. J Fam Nurs 2001;7:92-110.
13. Wilkins KL, Woodgate RL. An interruption in family life: Siblings' lived experience as they transition through the pediatric bone marrow transplant trajectory. Oncol Nurs Forum 2007;34:E28-E35.
14. Pentz RD, Chan KW, Neumann JL et al. Designing an ethical policy for bone marrow donation by minors and others lacking capacity. Camb Q Healthc Ethics 2004;13:149-155.
15. Ross LF. Children, Families, and Health Care Decision Making. Oxford, UK: Clarendon Press, 1998:1-197.
16. Ross LF, Glannon W. A compounding of errors: The case of bone marrow donation between non-intimate siblings. J Clin Ethics 2006;17:220-226.
17. Jansen LA. Child organ donation, family autonomy, and intimate attachments. Camb Q Healthc Ethics 2004;13:133-142.
18. Pentz R. Duty and altruism: Alternative analyses of the ethics of sibling bone marrow donation. J Clin Ethics 2006;17:227-230.
19. Dwyer J, Vig E. Rethinking transplantation between siblings. Hastings Cent Rep 1995;25:7-19.
20. Freedman B. Respectful service and reverent obedience. Hastings Cent Rep 1996;26:31-37.
21. Weijer C. Family duty is more important than rights. West J Med 2001;174:342-343.
22. Rhodes R. Genetic links, family ties, and social bonds: Rights and responsibilities in the face of genetic knowledge. J Med Philos 1998;23:10-30.
23. Pulsipher MA, Levine JE, Hayashi RJ et al. Safety and efficacy of allogeneic PBSC collection in normal pediatric donors: The Pediatric Blood and Marrow Transplant Consortium experience (PBMTC) 1996-2003. Bone Marrow Transplant 2005;35:361-367.
24. Pulsipher MA, Nagler A, Iannone R et al. Weighing the risks of G-CSF administration, leukopheresis, and standard marrow harvest: Ethical and safety considerations for normal pediatric hematopoietic cell donors. Pediatr Blood Cancer 2006;46:422-433.
25. Pentz RD. Healthy sibling donation of G-CSF primed stem cells: A call for research. Pediatr Blood Cancer 2006;46:407-408.
26. Donadieu J. Is G-CSF-mobilized peripheral stem cell harvest harmful? Pediatr Blood Cancer 2007;48:594-595; author reply 595-597.
27. Eapen M, Logan BR, Confer DL et al. Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival. Biol Blood Marrow Transplant 2007;13:1461-1468.
28. Institute of Medicine Committee on Clinical Research Involving Children. Ethical Conduct of Clinical Research Involving Children. Washington, DC: National Academies Press, 2004:1-448.
29. Ondrusek N, Abramovitch R, Pencharz P et al. Empirical examination of the ability of children to consent to clinical research. J Med Ethics 1998;24:158-165.
30. Tait AR, Voepel-Lewis T, Malviya S. Do they understand? (part II): Assent of children participating in clinical anesthesia and surgery research. Anesthesiology 2003;98:609-614.
31. Weithorn LA, Campbell SB. The competency of children and adolescents to make informed treatment decisions. Child Dev 1982;53:1589-1598.