Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir

American Journal of Health-System Pharmacy

Volumn 65, Issue 5, 2008, Pages 422-428

  Tappouni, Hiba L ^a   Rublein, John C ^b   Donovan, Brian J ^c   Hollowell, Stephanie B ^d   Tien, Hsiao Chuan ^e   Min, Sherene S ^f   Theodore, Dickens ^f   Rezk, Naser L ^g   Smith, Philip C ^h   Tallman, Melanie N ^h   Raasch, Ralph H ^g   Kashuba, Angela D M ⁱ  

^a GLAXOSMITHKLINE   (United States)

^b ABBOTT LABORATORIES   (United States)

^c CUBIST PHARMACEUTICALS INC   (United States)

^d Chippenham Johnston Willis Medical Center   (United States)

^e IL   (United States)

^f GLAXOSMITHKLINE   (United Kingdom)

^g Division of Pharmacotherapy and Experimental Therapeutics

^h Division of Molecular Pharmaceutics

ⁱ UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Antiretroviral agents; Blood levels; Dosage; Drug interactions; Gastrointestinal drugs; HIV infections; Indinavir; Omeprazole; Pharmacokinetics; Ritonavir

Indexed keywords

BILIRUBIN; INDINAVIR; OMEPRAZOLE; PLACEBO; RITONAVIR; ANTIULCER AGENT; PROTEINASE INHIBITOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISSOLUTION; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; GASTROINTESTINAL SYMPTOM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICAL ORDER; MONOTHERAPY; MORNING DOSAGE; NORMAL HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ADOLESCENT; DRUG COMBINATION; DRUG INTERACTION; MIDDLE AGED;

ADOLESCENT; ADULT; ANTI-ULCER AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; MALE; MIDDLE AGED; OMEPRAZOLE; RITONAVIR;

EID: 40349096415     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp070226     Document Type: Article

References (26)