Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage

Fertility and Sterility

Volumn 89, Issue 3, 2008, Pages 597-601

  Claahsen van der Grinten, Hedi L ^a   Otten, Barto J ^a   Hermus, Ad R M M ^a   Sweep, Fred C G J ^a   Hulsbergen van de Kaa, Christina A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Congenital adrenal hyperplasia; testicular adrenal rest tumors; testicular biopsies

Indexed keywords

ADULT; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; CONGENITAL ADRENAL HYPERPLASIA; DESCRIPTIVE RESEARCH; DISEASE SEVERITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; LYMPHOCYTIC INFILTRATION; MALE; NETHERLANDS; PRIORITY JOURNAL; SPERMATOGENESIS; TESTICULAR ADRENAL REST TUMOR; TESTIS BIOPSY; TESTIS INJURY; TESTIS TUMOR; UNIVERSITY HOSPITAL;

ADRENAL HYPERPLASIA, CONGENITAL; ADRENAL REST TUMOR; ADULT; BIOPSY; FIBROSIS; HUMANS; INFERTILITY, MALE; MALE; SEMINIFEROUS TUBULES; SEVERITY OF ILLNESS INDEX; SPERMATOGENESIS; TESTICULAR NEOPLASMS; TESTIS;

EID: 40249105989     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.03.051     Document Type: Article

References (28)

1. Cabrera M.S., Vogiatzi M.G., and New M.I. Long term outcome in adult males with classic congenital adrenal hyperplasia. J Clin Endocrinol Metab 86 (2001) 3070-3078
2. Stikkelbroeck N.M.M.L., Otten B.J., Pasic A., Jager G.J., Sweep C.G.J., Noordam K., et al. High prevalence of testicular adrenal rest tumours, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. J Clin Endocrinol Metab 86 (2001) 5721-5728
3. Otten B.J., Stikkelbroeck M.M.L., and Hermus A.R.M.M. Hypogonadism in males with congenital adrenal hyperplasia. In: Winters S.J. (Ed). Male hypogonadism: basic, clinical and therapeutic principles (2004), Humana Press, Totowa, NJ 125-137
4. Kim I., Young R.H., and Scully R.E. Leydig cell tumours of the testis. A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol 9 (1985) 177-192
5. Rich M.A., and Keating M.A. Leydig cell tumours and tumours associated with congenital adrenal hyperplasia. Urol Clin North Am 27 (2000) 519-528
6. Clark R.V., Albertson B.D., Munabi A., Cassorla F., Aguilera G., Warren D.W., et al. Steroidogenic enzyme activities, morphology and receptor studies of a testicular adrenal rest in a patient with congenital adrenal hyperplasia. J Clin Endocrinol Metab 70 (1990) 1408-1413
7. Combes-Moukhovsky M.E., Kottler M.L., Valensi P., Boudou P., Sibony M., and Attali J.R. Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumours and congenital adrenal hyperplasia. J Clin Endocrinol Metab 79 (1994) 1390-1394
8. Dominguez O.V. Biosynthesis of steroids by testicular tumours complicating congenital adrenal hyperplasia. J Clin Endocrinol Metab 21 (1961) 663-674
9. Rutgers J.L., Young R.H., and Scully R.E. The testicular tumour of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders. Am J Surg Pathol 12 (1988) 503-513
10. Murphy H., George C., de Kretser D.D., and Judd S. Successful treatment with ICSI of fertility caused by azoospermia associated with adrenal rests in the testes: case report. Hum Reprod 16 (2001) 263-267
11. Moore G.W., Lacroix A., Rabin D., and McKenna T.J. Gonadal dysfunction in adult men with congenital adrenal hyperplasia. Acta Endocrinol (Copenh) 95 (1980) 185-193
12. Bonaccorsi A.C., Adler I., and Figueiredo J.G. Male infertility due to congenital adrenal hyperplasia: testicular biopsy findings, hormonal evaluation, and therapeutic results in three patients. Fertil Steril 47 (1987) 664-670
13. Giacaglia L.R., Mendonca B.B., Madureira G., Melo K.F.F., Suslik C.A., Arnhold I.J.P., et al. Adrenal nodules in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: regression after adequate hormonal control. J Pediatr Endocrinol Metab 14 (2001) 415-419
14. Walker B.R., Skoog S.J., Winslow B.H., Canning D.A., and Tank E.S. Testis sparing surgery for steroid unresponsive testicular tumours of the adrenogenital syndrome. J Urol 157 (1997) 1460-1463
15. Stikkelbroeck N.M.L., Hermus A.R.M.M., Suliman H.M., Jager G.J., and Otten B.J. Asymptomatic testicular adrenal rest tumours in adolescent and adult males with congenital adrenal hyperplasia: basal and follow-up investigation after 2.6 years. J Pediatr Endocrinol Metab 17 (2004) 6645-6653
16. Battaglia M., Ditonno P., Palazzo S., Bettocchi C., Selvaggio O., Garofalo L., et al. Bilateral tumors of the testis in 21-hydroxylase deficiency without adrenal hyperplasia. Urol Oncol 23 (2005) 178-180
17. Tiryaki T., Aycan Z., and Huecumenglu S. Testis sparing surgery for steroid unresponsive testicular tumours of the congenital adrenal hyperplasia. Pediatr Surg Int 21 (2005) 853-855
18. Claahsen-van der Grinten H.L., Otten B.J., Takahashi S., Meuleman E.J.H., Hulsbergen-van de Kaa C., Sweep C.G.J., et al. Testicular adrenal rest tumours in adult males with congenital adrenal hyperplasia: evaluation of hormonal control and pituitary-gonadal function before and after testis-sparing surgery in 8 patients. J Clin Endocrinol Metab 92 (2006) 612-615
19. Knudsen J.L., Savage A., and Mobb G.E. The testicular tumour of adrenogenital syndrome-a persistent diagnostic pitfall. Histopathology 19 (1991) 468-470
20. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. (1999), Cambridge University Press, New York
21. Johnsen S.G. Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1 (1970) 2-25
22. Soderstrom K.O. Tubular hyalinization in human testis. Andrologia 18 (1986) 97-103
23. Haider S.G., Talati J., and Servos G. Ultrastructure of peritubular tissue in association with tubular hyalinization in human testis. Tissue Cell 31 (1999) 90-98
24. Behre H.M., Nieschlag E., and Meschede D. Obstructions of the seminal ducts. In: Nieschlag E., and Behre H. (Eds). Andrology. 2nd ed. (2001), Springer 179-181
25. Wong T.W., and Straus F.H. Testicular biopsy in the study of male infertility. Arch Pathol 95 (1973) 160-164
26. Dondero F, Lombardo F. Male infertility. In: Wass JA, Shalet SM. Oxford textbook of endocrinology and diabetes. 2003.
27. Belmonte I.G., Nistal M., and de Serrano M. Partial obstruction of the seminal path, a frequent cause of oligospermia in men. Hum Reprod 13 (1998) 3402-3405
28. Stikkelbroeck N.M.M.L., Suliman H.M., Otten B.J., Hermus A.R.M.M., Blickman J., and Jager G.J. Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features. Eur Radiol 13 (2003) 1597-1603