Two-step synthesis of structure-diverse d-galactose conjugates and polymeric prodrugs of floxuridine via controllable regioselective enzymatic acylation of 3′- or 5′-OH group of floxuridine

Enzyme and Microbial Technology

Volumn 42, Issue 5, 2008, Pages 414-420

  Xia, Aihua ^a   Wu, Qi ^a   Liu, Bokai ^a   Lin, Xianfu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Controllable regioselectivity; d Galactose floxuridine conjugates; Enzymatic synthesis; Floxuridine; Polymeric prodrugs

Indexed keywords

ACYLATION; CONJUGATED POLYMERS; DRUG PRODUCTS; ENZYME ACTIVITY; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

CONTROLLABLE REGIOSELECTIVITY; D-GALACTOSE-FLOXURIDINE CONJUGATES; ENZYMATIC SYNTHESIS; FLOXURIDINE; POLYMERIC PRODRUGS;

CARBOHYDRATES;

6 O [6 (3' O FLOXURIDINE) ADIPOYL] DEXTRO GALACTOSE; 6 O [6 (5' O FLOXURIDINE)ADIPOYL] DEXTRO GALACTOSE; ACETONITRILE; FLOXURIDINE; FLOXURIDINE DERIVATIVE; GALACTOSE; HYDROXYL GROUP; MONOMER; NITRILE; POLY(3' O VINYLADIPOYLFLOXURIDINE); POLY(5' O VINYLADIPOYLFLOXURIDINE); POLYMER; PRODRUG; PYRIDINE; SUBTILISIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CANDIDA ANTARCTICA; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME CHEMISTRY; ENZYME IMMOBILIZATION; POLYMERIZATION; STRUCTURE ANALYSIS;

BURKHOLDERIA CEPACIA; CANDIDA ANTARCTICA;

EID: 40249086533     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2007.12.001     Document Type: Article

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