Development of a rapidly dispersing tablet of a poorly wettable compound-formulation DOE and mechanistic study of effect of formulation excipients on wetting of celecoxib

International Journal of Pharmaceutics

Volumn 353, Issue 1-2, 2008, Pages 176-186

  He, Xiaorong ^a   Barone, Michael R ^b   Marsac, Patrick J ^b   Sperry, David C ^a  

^a PFIZER INC   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Agglomeration; Celecoxib; Disintegration; Dispersion; Poorly soluble; Porosity; Surface energy; Wetting

Indexed keywords

ANIONIC SURFACTANT; CELECOXIB; CROSPOVIDONE; DODECYL SULFATE SODIUM; MICROCRYSTALLINE CELLULOSE; POVIDONE;

ARTICLE; DISPERSIBLE TABLET; DRUG FORMULATION; DRUG GRANULATION; DRUG SCREENING; HUMAN; POWDER; PRIORITY JOURNAL; PROCESS MONITORING; STATISTICAL ANALYSIS; TABLET; TABLET DISINTEGRATION; TURBIDITY; WATER TRANSPORT; WETTABILITY;

CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; NEPHELOMETRY AND TURBIDIMETRY; POROSITY; PYRAZOLES; RESEARCH DESIGN; SULFONAMIDES; SURFACE-ACTIVE AGENTS; TABLETS; WETTABILITY;

EID: 40149085835     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.11.045     Document Type: Article

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