Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex

Science

Volumn 319, Issue 5867, 2008, Pages 1232-1235

  Debler, Erik W ^a,c   Kaufmann, Gunnar F ^a   Meijler, Michael M ^a,d   Heine, Andreas ^a,e   Mee, Jenny M ^a   Pljevaljčić, Goran ^a   Di Bilio, Angel J ^b   Schultz, Peter G ^a   Millar, David P ^a   Janda, Kim D ^a   Wilson, Ian A ^a   Gray, Harry B ^b   Lerner, Richard A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

STILBENE; TRYPTOPHAN;

ANTIBODY; ELECTRON; LUMINESCENCE; RECOMBINATION;

ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; BIOSENSOR; CRYSTAL STRUCTURE; ELECTRON TRANSPORT; FLUORESCENCE; ISOMERIZATION; LUMINESCENCE; PRIORITY JOURNAL; STEADY STATE;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; BINDING SITES, ANTIBODY; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; FLUORESCENCE; FLUORESCENCE POLARIZATION; HAPTENS; HYDROPHOBICITY; IMMUNOGLOBULIN VARIABLE REGION; LIGANDS; LUMINESCENCE; MUTATION; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; SPECTRUM ANALYSIS; STILBENES; TRYPTOPHAN;

EID: 40049105717     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1153445     Document Type: Article

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31. We thank S. Ferguson for assistance in Fab preparation and the staff at Advanced Light Source beamline 5.0.1 for their support. We gratefully acknowledge A. Deniz for providing access to his fluorimeter, and S. Mukhopadhyay for assistance with anisotropy measurements as well as helpful discussions. We thank J. Saltiel as well as the reviewers for critically reading the manuscript and providing helpful comments. Coordinates and structure factors for the EP2-25C10-1 complex have been deposited at the Protein Data Bank (PDB) with accession number 2NZR. Supported by NIH grants GM38273 (I.A.W.), GM56528 (P.G.S.), and DK19038 (H.B.G.) and a Skaggs predoctoral fellowship and Jairo H. Arévalo fellowship from The Scripps Research Institute graduate program (E.W.D.). This is publication 18959-MB from The Scripps Research Institute.