Adverse drug reactions in adult medical inpatients in a South African hospital serving a community with a high HIV/AIDS prevalence: Prospective observational study

British Journal of Clinical Pharmacology

Volumn 65, Issue 3, 2008, Pages 396-406

  Mehta, Ushma ^a   Durrheim, David N ^b   Blockman, Marc ^a   Kredo, Tamara ^a   Gounden, Ronald ^a   Barnes, Karen I ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Adverse drug reactions; Drug related morbidity; HIV AIDS; Hospitalisation; Pharmacovigilance

Indexed keywords

ADRENALIN; AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; ATROPINE; BENZODIAZEPINE; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPHENHYDRAMINE; EFAVIRENZ; ENALAPRIL; FLUCONAZOLE; FLUMAZENIL; FUROSEMIDE; GLUCOSE; HYDROCHLOROTHIAZIDE; INSULIN; METOCLOPRAMIDE; MIDAZOLAM; NALOXONE; PHENYTOIN; POLYSTYRENE; POLYSTYRENESULFONATE SODIUM; PROCHLORPERAZINE; PROMETHAZINE; PROTAMINE SULFATE; SPIRONOLACTONE; STAVUDINE; TUBERCULOSTATIC AGENT; UNINDEXED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; AKATHISIA; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ANTICHOLINERGIC EFFECT; ARTICLE; BRADYCARDIA; BRONCHOSPASM; CHOLINERGIC ACTIVITY; CLINICAL ASSESSMENT; COMMUNITY HOSPITAL; CONFUSION; CONTROLLED STUDY; DEMOGRAPHY; DEPRESSION; DIARRHEA; DISEASE SEVERITY; DRUG EFFECT; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG SAFETY; DRUG TOXICITY; FATTY LIVER; FEMALE; FLUID OVERLOAD; GOUT; HEART BLOCK; HEART DISEASE; HEART FAILURE; HEART VENTRICLE TACHYCARDIA; HEPATITIS; HEPATOMEGALY; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERGLYCEMIA; HYPERKALEMIA; HYPERLACTATEMIA; HYPERNATREMIA; HYPERSENSITIVITY REACTION; HYPOGLYCEMIA; HYPOKALEMIA; HYPONATREMIA; HYPOTENSION; INSOMNIA; KIDNEY DISEASE; KIDNEY FAILURE; LACTIC ACIDOSIS; LIVER CONGESTION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NAUSEA; NEUROLEPTIC MALIGNANT SYNDROME; PANCREATITIS; PERIPHERAL NEUROPATHY; PHLEBITIS; PREVALENCE; PRIORITY JOURNAL; RASH; SEDATION; SEIZURE; SIDE EFFECT; SUPRAVENTRICULAR TACHYCARDIA; TREATMENT OUTCOME; VOMITING;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AGED; ANTI-RETROVIRAL AGENTS; CARDIOVASCULAR AGENTS; COHORT STUDIES; FEMALE; HIV INFECTIONS; HOSPITAL MORTALITY; HOSPITALIZATION; HOSPITALS, TEACHING; HUMANS; MALE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; PREVALENCE; PROSPECTIVE STUDIES; SOUTH AFRICA;

EID: 40049098725     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2007.03034.x     Document Type: Article

References (41)

1. Chan TY, Chan JC, Tomlinson B, Critchley JA. Adverse reactions to drugs as a cause of admissions to a general teaching hospital in Hong Kong. Drug Saf 1992 7 : 235 40.
2. Lagnaoui R, Moore N, Fach J, Mongy-Boursier M, Bégaud B. Adverse drug reactions in a department of systemic diseases-oriented internal medicine: prevalence, incidence, direct costs and avoidability. Eur J Clin Pharmacol 2000 55 : 181 6.
3. Bond CA, Raehl CL. Adverse drug reactions in United States Hospitals. Pharmacotherapy 2006 26 : 601 8.
4. Tribino G, Maldonado C, Segura O, Diaz J. [Direct costs and clinical aspects of adverse drug reactions in patients admitted to a level 3 hospital internal medicine ward]. Biomedica 2006 26 : 31 41 [Article in Spanish] [Abstract].
5. Runciman WB, Roughead EE, Semple SJ, Adams RJ. Adverse drug events and medication errors in Australia. Int J Qual Health Care 2003 15 : i149 59.
6. Wiffen P, Gill M, Edwards J, Moore A. Adverse drug reactions in hospital settings: a systematic review of the prospective and retrospective studies. Bandolier Extra 2002 June : 1 16.
7. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998 279 : 1200 5.
8. Göttler M, Schneeweiss S, Hasford J. Adverse drug reaction monitoring-cost and benefit considerations. Part II: cost and preventability of adverse drug reactions leading to hospital admission. Pharmacoepidemiol Drug Saf 1997 6 (Suppl. 3 S79 90.
9. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006 367 : 1747 57.
10. UNAIDS. South Africa. UNAIDS. Available at http://www.unaids.org/en/ Regions_Countries/Countries/south_africa.asp (accessed 14 May 2007).
11. Dorrington RE, Johnson LF, Bradshaw D, Daniet T. The Demographic Impact of HIV/AIDS in South Africa. National and Provincial Indicators for 2006. Cape Town, South Africa : Centre for Actuarial Research, South African Medical, Research Council and Actuarial Society of South Africa, 2006. Available at http://www.assa.org.za/aids/content.asp?id=1000000449 (accessed 14 May 2007).
12. World Health Organization. WHO Report. Global Tuberculosis Control: Country Profile: South Africa. Geneva : World Health Organization, 2006. Available at http://www.who.International/GlobalAtlas/predefinedReports/TB/ index.asp?strSelectedCountry=ZAF (accessed 14 May 2007).
13. Shaikh N, Smith L. The 2005 HIV Antenatal Provincial and Area Surveys: Western Cape. Cape Town, South Africa : Department of Health: Provincial Government of the Western Cape, 2006 12.
14. Rozich JD, Haraden CR, Resar RK. Adverse drug event trigger tool: a practical methodology for measuring medication related harm. Qual Saf Health Care 2003 12 : 194 200.
15. Edwards IR, Biriell C. Harmonization in pharmacovigilance. Drug Saf 1994 10 : 93 102.
16. Rawlins MD, Thompson JW. Mechanisms of adverse drug reactions. In : Textbook of Adverse Drug Reactions, ed. Davies DM. Oxford : Oxford University Press, 1991 18 45.
17. Temple ME, Robinson RF, Miller JC, Hayes JR, Nahata MC. Frequency and preventability of adverse drug reactions in paediatric patients. Drug Saf 2004 27 : 819 29.
18. Schumock GT, Thornton JP. Focusing on the preventability of adverse drug reactions. Hosp Pharm 1992 27 : 538.
19. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 8 20 patients. BMJ 2004 329 : 15 9.
20. Carmargo AL, Ferreira MBC, Heineck I. Adverse drug reactions: a cohort study in internal medicine units at a University hospital. Eur J Clin Pharmacol 2006 62 : 143 9.
21. Bordet R, Gautier S, Le Louet H, Dupuis B, Caron J. Analysis of the direct costs of adverse drug reactions in hospitalized patients. Eur J Clin Pharmacol 2001 56 : 935 41.
22. Harb GE, Alldredge BK, Coleman R, Jacobson MA. Pharmacoepidemiology of adverse drug reactions in hospitalized patients with human immunodeficiency virus disease. J Acquir Immune Defic Syndr 1993 6 : 919 26.
23. Pirmohamed M, Park BK. HIV and drug allergy. Curr Opin Allergy Clin Immunol 2001 1 : 311 6.
24. Pouyanne P, Haramburu F, Imbs JL, Begaud B. Admissions to hospital caused by adverse drug reactions: cross sectional incidence study. BMJ 2000 320 : 1036.
25. Wu WK, Pantaleo N. Evaluation of outpatient adverse drug reactions leading to hospitalization. Am J Health Syst Pharm 2003 60 : 253 9.
26. Schneeweiss S, Göttler M, Hasford J, Swoboda W, Hippius M, Hoffman A, Riethling AK, Krappweiss J. First results from an intensified monitoring system to estimate drug-related hospital admissions. Br J Clin Pharmacol 2001 52 : 196 200.
27. Kanjanarat P, Winterstein AG, Johns TE, Hatton RC, Gonzalez-Rothi R, Segal R. Nature of preventable adverse drug events in hospitals: a literature review. Am J Health Syst Pharm 2003 60 : 1750 9.
28. Lundkvist J, Jönsson B. Pharmacoeconomics of adverse drug reactions. Fundam Clin Pharmacol 2004 18 : 275 80.
29. Atkin PA, Veitch PC, Veitch EM, Ogle SJ. The epidemiology of serious adverse drug reactions among the elderly. Drugs Aging 1999 14 : 141 52.
30. Somers A, Petrovic M, Robays H, Bogaert M. Reporting adverse drug reactions on a geriatric ward: a pilot project. Eur J Clin Pharmacol 2003 58 : 707 14.
31. Passarelli MC, Jacob-Filho W, Figueras A. Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause. Drugs Aging 2005 22 : 767 77.
32. Carr A, Cooper DA. Adverse effects of antiretroviral therapy. Lancet 2000 356 : 1423 30.
33. Yee D, Valiquette C, Pelletier M, Parisien I, Rocher I, Menzies D. Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am J Respir Crit Care Med 2003 167 : 1472 7.
34. Imhof A, Ledergerber B, Gunthard HF, Haupts S, Weber R Swiss HIV Cohorts Study. Risk factors for and outcome of hyperlactataemia in HIV-infected persons: is there a need for routine lactate monitoring? Clin Infect Dis 2005 41 : 721 8.
35. Azaz-Livshits T, Levy M, Sadan B, Shalit M, Geisslinger G, Brune K. Computerized surveillance of adverse drug reactions in hospital: pilot study. Br J Clin Pharmacol 1998 45 : 309 14.
36. Dormann H, Criegee-Rieck M, Neubert A, Egger T, Geise A, Krebs S, Schneider TH, Levy M, Hahn EG, Brune K. Lack of awareness of community-acquired adverse drug reactions upon hospital admission: dimensions and consequences of a dilemma. Drug Saf 2003 26 : 353 62.
37. Manosuthi W, Chottanapand S, Thongyen S, Chaovavanich A, Sungkanuparph S. Survival rate and risk factors of mortality among HIV/Tuberculosis-coinfected patients with and without antiretroviral therapy. J Acquir Immune Defic Syndr 2006 43 : 42 6.
38. Chan KC, Wong KH, Lee SS. Universal decline in mortality in patients with advanced HIV-1 disease in various demographic subpopulations after the introduction of HAART in Hong Kong, from 1993 to 2002. HIV Med 2006 7 : 186 92.
39. Palella FJ, Baker RK, Moorman AC, Chmiel JS, Wood KC, Brooks JT, Holmberg SD HIV Outpatient Study Investigators. Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr 2006 43 : 27 34.
40. Fattinger K, Roos M, Vergeres P, Holenstein C, Kind B, Masche U, Stocker DN, Braunschweig S, Kullak-Ublick GA, Galleazi RL, Follath F, Gasser T, Meier PJ. Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine. Br J Clin Pharmacol 2000 49 : 158 67.
41. Lee A, Rawlins MD, Smith JM. A study of expert judgements on adverse drug reaction reports and comparison with algorithmic methods. Br J of Clin Pharmacol 1992 34 : 157.