Investigation into the influence of a high fat diet on antipsychotic- induced weight gain in female rats

Journal of Psychopharmacology

Volumn 22, Issue 2, 2008, Pages 182-186

  Fell, M J ^a,b   Neill, J C ^a   Anjum, N ^a   Peltola, L M ^a   Marshall, K M ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Antipsychotic; High fat diet; Obesity; Olanzapine; Rat; Risperidone; Ziprasidone

Indexed keywords

NEUROLEPTIC AGENT; OLANZAPINE; RISPERIDONE; ZIPRASIDONE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FLUID INTAKE; FOOD INTAKE; HYPOPHAGIA; INGESTION; INTRAABDOMINAL FAT; LIPID DIET; LIPID STORAGE; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; WEIGHT GAIN; WEIGHT REDUCTION;

ABDOMINAL FAT; ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; DIETARY FATS; DRINKING BEHAVIOR; FEEDING BEHAVIOR; FEMALE; INJECTIONS, INTRAPERITONEAL; PIPERAZINES; RATS; RISPERIDONE; THIAZOLES; WEIGHT GAIN;

EID: 40049095328     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881107082287     Document Type: Article

References (31)

1. Abdul-Monim Z., Reynolds G.P., Neill J.C. (2003) The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat. J Psychopharmacol 17: 57 - 65
2. Allison D.B., Mentore J.L., Heo M., Chandler L.P., Cappelleri J.C., Infante M.C., Weiden P.J. (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiat 156: 1686 - 1696
3. Arjona A.A., Wurtman R.J., Zhang S.X., Adamson B. (2004) An animal model of antipsychotic-induced weight gain. Behav Brain Res 152: 121 - 127
4. Baptista T., Contreras Q., Teneud L., Albornoz M.A., Acosta A., Paez X., de Quijada M., LaCruz A., Hernandez L. (1998) Mechanism of the neuroleptic-induced obesity in female rats. Prog Neuropsychopharmacol Biol Psychiat 22: 187 - 198
5. Baptista T., Araujo de Baptista E., Ying Kin N.M., Beaulieu S., Walker D., Joober R., Lalonde J., Richard D. (2002) Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance. Brain Res 957: 144 - 151
6. Baptista T., de Baptista E.A., Lalonde J., Plamondon J., Kin N.M., Beaulieu S., Joober R., Richard D. (2004) Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection. Prog. Neuro-Psychoph 28: 1305 - 1311
7. Brown S., Birtwistle J., Roe L., Thompson C. (1999) The unhealthy lifestyle of people with schizophrenia. Psychol Med 29: 697 - 701
8. Cooper G.D., Pickavance L.C., Wilding J.P., Halford J.C., Goudie A.J. (2005) A parametric analysis of olanzapine-induced weight gain in female rats. Psychopharmacology (Berl) 181: 80 - 89
9. Cooper G.D., Pickavance L.C., Wilding J.P., Harrold J.A., Halford G., Goudie A.J. (2006) Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities. J Psychopharmacol 21: 405 - 413
10. Fell M.J., Marshall K.M., Neill J.C. (2004 a) Effects of the classical antipsychotic haloperidol and atypical antipsychotic risperidone on weight gain, the oestrous cycle and uterine weight in female rats. Eur Neuropsychopharmacol 14: 385 - 392
11. Fell M.J., Neill J.C., Marshall K.M., Williams J. (2004 b) Effects of the atypical antipsychotic olanzapine on reproductive function and weight gain in female rats. J Psychopharmacol 18: 149 - 155
12. Fell M.J., Gibson R., McDermott E., Sisodia G., Marshall K.M., Neill J.C. (2005 a) Investigation into the effects of the novel antipsychotic ziprasidone on weight gain and reproductive function in female rats. Behav Brain Res 160: 338 - 343
13. Fell M.J., Neill J.C., Rao C., Marshall K.M. (2005 b) Effects of sub-chronic antipsychotic drug treatment on body weight and reproductive function in juvenile female rats. Psychopharmacology (Berl) 182: 499 - 507
14. Fell M.J., Anjum N., Dickinson K., Marshall K.M., Peltola L.M., Vickers S., Cheetham S., Neill J.C. (2007) The distinct effects of subchronic antipsychotic drug treatment on macronutrient selection, body weight, adiposity, and metabolism in female rats. Psychopharmacology (Berl) 194: 221-231
15. Goudie A.J., Smith J.A., Halford J.C. (2002) Characterization of olanzapine-induced weight gain in rats. J Psychopharmacol 16: 291 - 296
16. Graham K.A., Perkins D.O., Edwards L.J., Barrier R.C., Jr., Lieberman J.A., Harp J.B. (2005) Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosis. Am J Psychiat 162: 118 - 123
17. Henderson D.C., Cagliero E., Gray C., Nasrallah R.A., Hayden D.L., Schoenfeld D.A., Goff D.C. (2000) Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study. Am J Psychiat 157: 975 - 981
18. Kalinichev M., Rourke C., Daniels A.J., Grizzle M.K., Britt C.S., Ignar D.M., Jones D.N. (2005) Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats. Psychopharmacology (Berl) 182: 220 - 231
19. Kalinichev M., Rourke C., Jones D.N. (2006) Body weights and plasma prolactin levels in female rats treated subchronically with ziprasidone versus olanzapine. Behav Pharmacol 17: 289 - 292
20. Kapur S., VanderSpek S.C., Brownlee B.A., Nobrega J.N. (2003) Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy. J Pharmacol Exp Ther 305: 625 - 631
21. Kaur G., Kulkarni S.K. (2002) Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Prog Neuropsychopharmacol Biol Psychiat 26: 277 - 285
22. Kirk S.L., Neill J.C., Jones D N C, Reynolds G.P. (2004) Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat. Eur J Pharmacol 505: 253 - 254
23. McCreadie R.G. (2003) Diet, smoking and cardiovascular risk in people with schizophrenia: descriptive study. Br J Psychiat 183: 534 - 539
24. Minet-Ringuet J., Even P.C., Guesdon B., Tome D., de Beaurepaire R. (2005) Effects of chronic neuroleptic treatments on nutrient selection, body weight, and body composition in the male rat under dietary self-selection. Behav Brain Res 163: 204 - 211
25. Minet-Ringuet J., Even P.C., Goubern M., Tome D., de Beaurepaire R. (2006 a) Long term treatment with olanzapine mixed with the food in male rats induces body fat deposition with no increase in body weight and no thermogenic alteration. Appetite 46: 254 - 262
26. Minet-Ringuet J., Even P.C., Lacroix M., Tome D., de Beaurepaire R. (2006 b) A model for antipsychotic-induced obesity in the male rat. Psychopharmacology (Berl) 187: 447 - 454
27. Parada M.A., Hernandez L., Paez X., Baptista T., Puig de Parada M., de Quijada M.U. (1989) Mechanism of the body weight increase induced by systemic sulpiride. Pharmacol, Biochem Behav 33: 45 - 50
28. Pouzet B., Mow T., Kreilgard M., Velschow S. (2003) Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human. Pharmacol Biochem and Behav 75: 133 - 140
29. Taylor D.M., McAskill R. (2000) Atypical antipsychotics and weight gain a systematic review. Acta Psychiat Scand 101: 416 - 432
30. Thornton-Jones Z., Neill J.C., Reynolds G.P. (2002) The atypical antipsychotic olanzapine enhances ingestive behaviour in the rat: a preliminary study. J Psychopharmacol 16: 35 - 37
31. Wirshing D.A., Wirshing W.C., Kysar L., Berisford M.A., Goldstein D., Pashdag J., Mintz J., Marder S. (1999) Novel antipsychotics: comparison of weight gain liabilities. J Clin Psychiat 60: 358 - 363