Prospective single-arm study of 72 Gy hyperfractionated radiation therapy and combination chemotherapy for anaplastic astrocytomas

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Nomiya, Takuma ^a   Nemoto, Kenji ^a   Kumabe, Toshihiro ^a   Takai, Yoshihiro ^a   Yamada, Shogo ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE; NIMUSTINE; ANTINEOPLASTIC AGENT;

ADULT; ARTICLE; BRAIN EDEMA; BRAIN NECROSIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; DISEASE FREE SURVIVAL; FEMALE; GLIOBLASTOMA; HUMAN; MALE; MULTIMODALITY CANCER THERAPY; OVERALL SURVIVAL; PROGNOSIS; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION RESPONSE; TREATMENT FAILURE; TREATMENT OUTCOME; ASTROCYTOMA; BRAIN TUMOR;

ADULT; ANTINEOPLASTIC AGENTS; ASTROCYTOMA; BRAIN NEOPLASMS; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; HUMANS; MALE; NIMUSTINE;

EID: 40049084512     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-11     Document Type: Article

References (20)

1. Werner-Wasik M Scott CB Nelson DF Gaspar LE Murray KJ Fischbach JA Nelson JS Weinstein AS Curran WJ Jr Final report of a phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas. Radiation Therapy Oncology Group Study 83-02 Cancer 1996, 77(8):1535-1543. 10.1002/ (SICI)1097-0142(19960415)77:8<1535::AID-CNCR17>3.0.CO;2-0 8608540
2. Tortosa A Vinolas N Villa S Verger E Gil JM Brell M Caral L Pujol T Acebes JJ Ribalta T Ferrer I Graus F Prognostic implication of clinical, radiologic, and pathologic features in patients with anaplastic gliomas Cancer 2003, 97(4):1063-1071. 10.1002/cncr.11120 12569607
3. Levin VA Yung WK Bruner J Kyritsis A Leeds N Gleason MJ Hess KR Meyers CA Ictech SA Chang E Maor MH Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas Int J Radiat Oncol Biol Phys 2002, 53(1):58-66. 10.1016/S0360-3016(01)02819-X 12007942
4. Simpson JR Horton J Scott C Curran WJ Rubin P Fischbach J Isaacson S Rotman M Asbell SO Nelson JS Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive radiation therapy oncology group (RTOG) clinical trials Int J Radiat Oncol Biol Phys 1993, 26:239-244. 8387988
5. Wood JR Green SB Shapiro WR The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the Brain Tumor Cooperative Group J Clin Oncol 1988, 6(2):338-343. 3339397
6. Miller PJ Hassanein RS Giri PG Kimler BF O'Boynick P Evans RG Univariate and multivariate statistical analysis of high-grade gliomas: The relationship of radiation dose and other prognostic factors Int J Radiat Oncol Biol Phys 1990, 19(2):275-280. 2168352
7. Leon SP Folkerth RD Black PM Microvessel density is a prognostic indicator for patients with astroglial brain tumors Cancer 1996, 77(2):362-372. 10.1002/ (SICI)1097-0142(19960115)77:2<362::AID-CNCR20>3.0.CO;2-Z 8625246
8. Curran WJ Jr Scott CB Horton J Nelson JS Weinstein AS Fischbach AJ Chang CH Rotman M Asbell SO Krisch RE Nelson DF Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials J Natl Cancer Inst 1993, 85(9):704-710. 10.1093/ jnci/85.9.704 8478956
9. Brada M Sharpe G Rajan B Britton J Wilkins PR Guerrero D Hines F Traish D Ashley S Modifying radical radiotherapy in high grade gliomas; shortening the treatment time through acceleration Int J Radiat Oncol Biol Phys 1999, 43(2):287-292. 10.1016/S0360-3016(98)00390-3 10030251
10. Nelson DF Curran WJ Jr Scott C Nelson JS Weinstein AS Ahmad K Constine LS Murray K Powlis WD Mohiuddin M Hyperfractionated radiation therapy and bis-chlorethyl nitrosourea in the treatment of malignant glioma-possible advantage observed at 72.0 Gy in 1.2 Gy B.I.D. fractions: Report of the Radiation Therapy Oncology Group Protocol 8302 Int J Radiat Oncol Biol Phys 1993, 15(25):193-207.
11. Zietman AL Suit HD Tomkinson KN Thames HD Sedlacek RS The response of two human tumor xenografts to fractionated irradiation. The derivation of alpha/beta ratios from growth delay, tumor control, and in vitro cell survival assays Int J Radiat Oncol Biol Phys 1990, 18(3):569-575. 2318689
12. Stuschke M Budach V Budach W Feldmann HJ Sack H Radioresponsiveness, sublethal damage repair and stem cell rate in spheroids from three human tumor lines: Comparison with xenograft data Int J Radiat Oncol Biol Phys 1992, 24(1):119-126. 1512147
13. Stuschke M Budach V Sack H Radioresponsiveness of human glioma, sarcoma, and breast cancer spheroids depends on tumor differentiation Int J Radiat Oncol Biol Phys 1993, 27(3):627-636. 8226158
14. Jeremic B Shibamoto Y Grujicic D Milicic B Stojanovic M Nikolic N Dagovic A Aleksandrovic J Pre-irradiation carboplatin and etoposide and accelerated hyperfractionated radiation therapy in patients with high-grade astrocytomas: A phase II study Radiother Oncol 1999, 51(1):27-33. 10.1016/S0167-8140(99)00029-8 10386714
15. Urtasun RC Kinsella TJ Farnan N DelRowe JD Lester SG Fulton DS Survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: Final report of RTOG 86-12, Phase I-II study Int J Radiat Oncol Biol Phys 1996, 36(5):1163-1167. 10.1016/ S0360-3016(96)00429-4 8985039
16. Prados MD Scott CB Rotman M Rubin P Murray K Sause W Asbell S Comis R Curran W Nelson J Davis RL Levin VA Lamborn K Phillips TL Radiation therapy and hydroxyurea followed by the combination of 6-thioguanine and BCNU for the treatment of primary malignant brain tumors Int J Radiat Oncol Biol Phys 1998, 40(1):57-63. 10.1016/S0360-3016(97)00566-X 9422558
17. Aydin H Sillenberg I von Lieven H Patterns of failure following CT-based 3-D irradiation for malignant glioma Strahlenther Onkol 2001, 177(8):424-431. 10.1007/PL00002424 11544905
18. Lee SW Fraass BA Marsh LH Herbort K Gebarski SS Martel MK Radany EH Lichter AS Sandler HM Patterns of failure following high-dose 3-D conformal radiotherapy for high-grade astrocytomas: A quantitative dosimetric study Int J Radiat Oncol Biol Phys 1999, 43(1):79-88. 9989517
19. Sneed PK Gutin PH Larson DA Malec MK Phillips TL Prados MD Scharfen CO Weaver KA Wara WM Patterns of recurrence of glioblastoma multiforme after external irradiation followed by implant boost Int J Radiat Oncol Biol Phys 1994, 29(4):719-727. 8040017
20. Sakamaki H Onozawa Y Yano Y Imai K Sasaki T Ibuka T Funada N Matsuda T Disseminated necrotizing leukoencephalopathy following irradiation and methotrexate therapy for central nervous system infiltration of leukemia and lymphoma Radiat Med 1993, 11(4):146-153. 8234858