A study of the pathogenesis of Rosacea: How angiogenesis and mast cells may participate in a complex multifactorial process

Archives of Dermatological Research

Volumn 300, Issue 3, 2008, Pages 125-131

  Aroni, Kyriaki ^a   Tsagroni, Eugenia ^a   Kavantzas, Nikolaos ^a   Patsouris, Efstratios ^a   Ioannidis, Eleftherios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Angiogenesis; Mast cells; Rosacea

Indexed keywords

ADULT; ANGIOGENESIS; ANTIBODY DETECTION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; ELASTOSIS; FACE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MAST CELL; MORPHOMETRICS; PRIORITY JOURNAL; PUNCH BIOPSY; RANDOMIZED CONTROLLED TRIAL; ROSACEA; SAMPLE SIZE; SKIN BIOPSY; SKIN BLOOD VESSEL; SKIN GRANULOMA; STATISTICAL SIGNIFICANCE; TISSUE SECTION;

ADULT; FACTOR VIII; FEMALE; HUMANS; MALE; MAST CELLS; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; ROSACEA; SKIN;

EID: 39949085789     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-007-0816-z     Document Type: Article

References (36)

1. Aloi F, Tomasini C (2000) The clinicopathologic spectrum of rhinophyma. J Am Acad Dermatol 42:468-472
2. Aroni K, Tsagroni E, Lazaris A, Patsuris E, Agapitos E (2004) Rosacea: a clinicopathological approach. Dermatology 209:177-182
3. Artuc M, Hermes B, Steckelings UM (1999) Mast cells and their mediators in cutaneous wound healing-active participants or innocent bystanders? Exp Dermatol 8:1-16
4. Ballaun C, Weninger W (1995) Human Keratinocytes express the three major splice forms of VEGF. J Invest Dermatol 104:7-10
5. Bamford J (2001) Rosacea: current thoughts on origin. Sem Cut Med Surg 20(3):199-206
6. Bancroft JD, Stevens A (1982) Theory and practice of histological techniques, 2nd edn. Churchill Livingstone, Edinburgh, p 402
7. Barton SP, Abdullah MS, Marks R (1992) Quantification of microvascular changes in the skin in patients with psoriasis. Br J Dermatol 126:569-574
8. Bielauberg DR, Sanchez R (1998) Molecular regulation of UVB-induced cutaneous angiogenesis. J Invest Dermatol 111:864-872
9. Bonnar A, Eustace P (1993) The Demodex mite population in Rosacea. JAAD 28:443-448
10. Brown LF, Harrist TJ, Yeo KT, Stable-Backdahl M, Jackman RW, Berse B, Tognazzi K, Dvorak HF, Detmar M (1995) Increased expression of VPF in bullous pemphigoid, dermatitis herpetiformis and erythema multiform. J Invest Dermatol 104:744-749
11. Clauss M, Gerlach M, et al (1990) VPF: a tumor derived polypeptide that induces endothelial cell and monocyte procoagulant activity and promotes monocyte migration. J Exp Med 172:1535-1545
12. Crawford GH, Pelle MT (2004) Rosacea I. Etiology, pathogenesis and subtype classification. JAAD 51:327-341
13. Detmar M (1996) Molecular regulation of angiogenesis in the skin. J Invest Dermatol 106:207-208
14. Erbagci Z, Ozgoztasi O (1998) The significance of Demodex folliculorum density in rosacea. Int J Dermatol 37:421-425
15. Folkman J (1995) Clinical applications of research on angiogenesis. N Engl J Med 333:1757-1763
16. Forton F, Seys B (1993) Density of Demodex folliculorum in Rosacea:a case-control study using standardized skin-surface biopsy. Br J Dermatol 128:650-659
17. Georgala S, Katoulis AC (2001) Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. JEADV 15:441-444
18. Gruber LB, Marchese JM, Kew R (1995) Angiogenic factors stimulate Mast-cell migration. Blood 86(7):2488-2493
19. Hagiwara K, Khaskhely MN, Vezato H, Nonaka S (199) Mast cell "Densities" in vascular proliferations: a preliminary study of pyogenic granuloma, Portwine stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma and Malignant Hemangioendothelioma. J Dermatol 26:577-586
20. Jiang YW, Chattedee DA, Raychaudhuri PS (2001) Mast cell density and IL-8 expression in nonlesional and lesional psoriatic skin. Int J Dermatol 40:699-703
21. Katz AM (1998) Rosacea: epidemiology and pathogenesis. J Cut Med Surg 2(Suppl4):S4-S10
22. Kessler AD, Lauger SR, Pless AN, Folkman S (1976) Mast cell and tumor angiogenesis. Int J Cancer 18:703-709
23. Kosmadaki MG (2003) UV induces VEGF through a TNF-a independent pathway. FASEB J 17:446-448
24. Leek RD, Hunt NC, et al (2000) Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J Pathol 190(4):430-436
25. Meininger CJ, Zetter BR, et al (1992) Mast cells and angiogenesis. Semin Cancer Biol 3:73-77
26. Motley RJ, Banton S, Marks R (1989) The significance of telangiectasia in rosacea. In: Marks R, Plewig G (eds) Acne and related disorders. Martin Dunitz, London, pp 339-344
27. Neumman E, Frithz A (1998) Capillaropathy and Capillaroneogenesis in the pathogenesis of Rosacea. Int J Dermatol 37:263-266
28. Ono M, Torisu H (1999) Biological impliations of macrophage infiltration in human tumor angiogenesis. Cancer Chemother Pharmacol 43:S69-S71
29. Rothe JM, Nowak M, Kerdel AF (1990) The mast cell in health and disease. JAAD 23(4):615-624
30. Shea RC, Prieto GV (1994) Mast cells in angiolipomas and hemangiomas of human skin: are they important for angiogenesis? J Cut Pathol 21:247-251
31. Smith JR, Lanier VB (2007) Expression of VEGF and its receptors in rosacea. Br J Ophthalmol 91:226-229
32. Tope WD, Sangueza OP (1994) Rhinophyma's fibrous variant histopathology and immunohistochemistry. Am J Dermatopathol 16(3):307-310
33. Walton S, DeSouza JE (1983) Variation in mast cell numbers in psoriasis and lichen planus: comparisons with normal skin. Dermatologica 166:236-239
34. Weber S, Kruger-Krasagakes S, Grabbe J (1995) Mast cells. Int J Dermatol 34(1):1-10
35. Wilkin J, Dahl M (2002) Standard classification of rosacea: report of the national Rosacea society expert committee on the classification and staging of Rosacea. JAAD 46:584-587
36. Wilkin J (1994) Rosacea. Pathophysiology and treatment. Arch Dermatol 130:359-362