A novel method for preparing immune stimulating complexes (ISCOMs) by hydration of freeze-dried lipid matrix

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 68, Issue 3, 2008, Pages 840-845

  Liang, Mingtao ^a   Toth, Istvan ^a   Davies, Nigel M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

ISCOMs; Lipid matrix; Lipopeptide; Lyophilization; Vaccine

Indexed keywords

CHOLESTEROL; ISCOM; LIPID; LIPOPEPTIDE; PHOSPHOLIPID; QUIL A;

ARTICLE; COLLOID; FREEZE DRYING; HYDRATION; MICROENCAPSULATION; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

CHEMISTRY, PHARMACEUTICAL; FREEZE DRYING; ISCOMS; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 39949083215     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.11.017     Document Type: Article

References (12)

1. Morein B., Hu K.-F., and Abusugra I. Current status and potential application of ISCOMs in veterinary medicine. Adv. Drug Deliv. Rev. 56 (2004) 1367-1382
2. Skene C.D., and Sutton P. Saponin-adjuvanted particulate vaccines for clinical use. Methods 40 (2006) 53-59
3. Hoeglund S., Dalsgaard K., Lovgren K., Sundquist B., Osterhaus A., and Morein B. ISCOMs and immunostimulation with viral antigens. Subcell. Biochem. 15 (1989) 39-68
4. Lendemans D.G., Myschik J., Hook S., and Rades T. Immuno-stimulating complexes prepared by ethanol injection. J. Pharm. Pharmacol. 57 (2005) 729-733
5. Pham H.L., Shaw P.N., and Davies N.M. Preparation of immuno-stimulating complexes (ISCOMs) by ether injection. Int. J. Pharm. 310 (2006) 196-202
6. Copland M.J., Rades T., and Davies N.M. Hydration of lipid films with an aqueous solution of Quil A: a simple method for the preparation of immune-stimulating complexes. Int. J. Pharm. 196 (2000) 135-139
7. Demana P.H., Davies N.M., Hook S., and Rades T. Quil A-lipid powder formulations releasing ISCOMs and related colloidal structures upon hydration. J. Control. Release 103 (2005) 45-59
8. Liang M.T., Davies N.M., and Toth I. Encapsulation of lipopeptides within liposomes: effect of number of lipid chains, chain length and method of liposome preparation. Int. J. Pharm. 301 (2005) 247-254
9. Demana P.H., Davies N.M., Vosgerau U., and Rades T. Pseudo-ternary phase diagrams of aqueous mixtures of Quil A, cholesterol and phospholipid prepared by the lipid-film hydration method. Int. J. Pharm. 270 (2004) 229-239
10. Kersten G.F.A., Spiekstra A., Coen Beuvery E., and Crommelin D.J.A. On the structure of immune-stimulating saponin-lipid complexes (iscoms). Biochim. Biophys. Acta (BBA) Biomembr. 1062 (1991) 165-171
11. Sum A.K., Faller R., and de Pablo J.J. Molecular simulation study of phospholipid bilayers and insights of the interactions with disaccharides. Biophys. J. 85 (2003) 2830-2844
12. Demana P.H., Davies N.M., Berger B., Vosgerau U., and Rades T. A comparison of pseudo-ternary diagrams of aqueous mixtures of Quil A, cholesterol and phospholipid prepared by lipid-film hydration and dialysis. J. Pharm. Pharmacol. 56 (2004) 573-580