Expression of KAI1 in urothelial cancer tissues and its relationship with invasion and metastasis of urothelial cancer

Academic Journal of Second Military Medical University

Volumn 29, Issue 2, 2008, Pages 189-192

  Yuan, Hong Gang ^a   Song, Xing Fu ^a   Zhang, Ping ^a   Long, Bing ^a   Dong, Zi Qiang ^a   Xu, Xiao Ming ^a   Zhou, Tian Gui ^a   Chen, Xian Guo ^b  

^a CHINA THREE GORGES UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Kangai l protein; Neoplasm invasiveness; Neoplasm metastasis; Urothelial cancer

Indexed keywords

CD82 ANTIGEN; MESSENGER RNA;

ADULT; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER INFILTRATION; CANCER INVASION; CANCER STAGING; CANCER TISSUE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE ANALYSIS; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSITIONAL CELL CARCINOMA; TUMOR DIFFERENTIATION; UROGENITAL TRACT CANCER;

EID: 39849100417     PISSN: 0258879X     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1008.2008.00189     Document Type: Article

References (14)

1. Dong J T, Lamb P W, Rinker-Schaeffer C W, Vukanovic J, Ichikawa T, Isaacs J T, et al. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11P11. 2[J]. Science,1995,268:884-886.
2. Chinese source.
3. Xiong Y, Liang L Z, Yan X J, Yuan S H, Wei M. Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance[J]. Ai Zheng,2005, 24:110-115.
4. Takeda T, Hattori N, Tokuhara T, Nishimura Y, Yokoyama M, Miyake M. Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model[J]. Cancer Res,2007,67:1744-1749.
5. Chinese source.
6. Leavey P J, Timmons C, Frawley W, Lombardi D, Ashfaq R. KAI-1 expression in pediatric high-grade osteosarcoma[J]. Pediatr Dev Pathol,2006,9:219-224.
7. Mohan A, Nalini V, Mallikarjuna K, Jyotirmay B, Krishnakumar S. Expression of motility-related protein MRP1/CD9, N-cadherin, E-cadherin, alpha-catenin and beta-catenin in retino-blastoma[J]. Exp Eye Res,2007,84:781-789.
8. Ow K, Delprodo W, Fisher R, Barrett J, Yu Y, Jackson P, et al. Relationship between expression of the KAI1 metastasis suppressor and other markers of advanced bladder cancer[J]. J Pathol,2000,191:39-47.
9. Su J S, Arima K, Hasegawa M, Franco O E, Umeda Y, Yanagawa M, et al. Decreased expression of KAI1 metastasis suppressor gene is a recurrence predictor in primary pTa and pT1 urothelial bladder carcinoma[J]. Int J Urol,2004,11:74-82.
10. Chinese source.
11. Rowe A, Jackson P. Expression of KITENIN, a KAI1/CD82 binding protein and metastasis enhancer, in bladder cancer cell lines:relationship to KAI1/CD82 levels and invasive behaviour [J]. Oncol Rep,2006,16:1267-1272.
12. Yu Y, Yang J L, Markovic B, Jackson P, Yardley G, Barrett J, et al. Loss of KAI1 messenger RNA expression in both highgrade and invasive human bladder cancers[J]. Clin Cancer Res, 1997,3:1045-1049.
13. Jackson P, Rowe A, Grimm M O. An alternatively spliced KAI1 mRNA is expressed at low levels in human bladder cancers and bladder cancer cell lines and is not associated with invasive behaviour[J]. Oncol Rep,2007,18:1357-1363.
14. Jackson P, Grimm M O, Kingsley E A, Brosius U, Antalis T, Yardley G, et al. Relationship between expression of KAI1 metastasis suppressor gene,mRNA levels and p53 in human bladder and prostate cancer cell lines[J]. Urol Oncol,2002,7:99-104.