Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27

Digestive Diseases and Sciences

Volumn 53, Issue 3, 2008, Pages 606-613

  Yeo, Marie ^a   Kim, Dong Kyu ^a   Cho, Sung Won ^a   Hong, Hee Do ^b  

^a Ajou University School of Medicine   (South Korea)

^b Korea Food Research Institute   (South Korea)

Author keywords

Alcohol induced gastric damage; Cytoprotection; Ginseng; Heat shock proteins

Indexed keywords

ALCOHOL; GINSENG EXTRACT; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; GINSENG; MALE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; STOMACH INJURY;

ANIMALS; CELL DEATH; CYCLOOXYGENASE 2; CYTOPROTECTION; ETHANOL; GASTRIC MUCOSA; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; MALE; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 39849097515     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9946-6     Document Type: Article

References (34)

1. Behrman SW (2005) Management of complicated peptic ulcer disease. Arch Surg 140:201-208
2. Guslandi M (1987) Effects of ethanol on the gastric mucosa. Dig Dis 5:21-32
3. Laine L, Weinstein WM (1988) Histology of alcoholic hemorrhagic "gastritis": a prospective evaluation. Gastroenterology 94:1254-1262
4. Guth PH, Paulsen G, Nagata H (1984) Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection. Gastroenterology 87:1083-1090
5. Chamberlain CE (1993) Acute hemorrhagic gastritis. Gastroenterol Clin North Am 22:843-873
6. Tepperman BL, Soper BD (1993) Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity. Br J Pharmacol 110:229-234
7. Cho CH, Chen BW, Hui WM, Luk CT, Lam SK (1990) Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats. Prostaglandins 40:397-403
8. Attele AS, Wu JA, Yuan CS (1999) Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58:1685-1693
9. Tsang D, Yeung HW, Tso WW, Peck H (1985) Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 51:221-224
10. Ota T, Fujikawa-yamamoto K, Zong ZP, Yamazaki M, Odashima S, Kitagawa I, Abe H, Arichi S (1987) Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells. Cancer Res 47:3863-3867
11. Kenarova B, Neychev H, Hadjiivanova C, Petkov VD (1990) Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 54:447-454
12. Mehendale SR, Wang CZ, Shao ZH, Li CQ, Xie JT, Aung HH, Yuan CS (2006) Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes. Eur J Pharmacol 553:209-214
13. Rausch WD, Liu S, Gille G, Radad K (2006) Neuroprotective effects of ginsenosides. Acta Neurobiol Exp (Wars) 66:369-375
14. Yun TK (2001) Panax ginseng-a non-organ-specific cancer preventive? Lancet Oncol 2:49-55
15. Lee YJ, Pantuck CB, Pantuck EJ (1993) Effect of ginseng on plasma levels of ethanol in the rat. Planta Med 59:17-19
16. Lee FC, Ko JH, Park JK, Lee JS (1987) Effects of Panax ginseng on blood alcohol clearance in man. Clin Exp Pharmacol Physiol 14:543-546
17. Lee SC, Moon YS, You KH (2000) Effects of red ginseng saponins and nootropic drugs on impaired acquisition of ethanol-treated rats in passive avoidance performance. J Ethnopharmacol 69:1-8
18. Altura BM, Gebrewold A, Zhang A, Altura BT (2002) Ethanol induces rapid lipid peroxidation and activation of nuclear factor-kappa B in cerebral vascular smooth muscle: relation to alcohol-induced brain injury in rats. Neurosci Lett 325:95-98
19. Nanji AA, Jokelainen K, Fotouhinia M, Rahemtulla A, Thomas P, Tipoe GL, Su GL, Dannenberg AJ (2001) Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines. Am J Physiol Gastrointest Liver Physiol 281:G1348-G1356
20. McCullough AJ, O'Connor JF (1998) Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 93:2022-2036
21. Schenker S, Montalvo R (1998) Alcohol and the pancreas. Recent Dev Alcohol 14:41-65
22. Bujanda L (2000) The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol 95:3374-3382
23. Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ (2002) Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology 122:106-118
24. Wu D, Cederbaum AI (2003) Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. J Biol Chem 278:1115-1124
25. Shaw S, Herbert V, Colman N, Jayatilleke E (1990) Effect of ethanol-generated free radicals on gastric intrinsic factor and glutathione. Alcohol 7:153-157
26. Hernández-Muñoz R, Montiel-Ruíz C, Vázquez-Martínez O (2000) Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab Invest 80:1161-1169
27. Laudanno OM, Bedini OA, San Miguel P, Cesolari JA (1987) Gastric cytoprotection induced by prostaglandin-dopaminergic mechanism. Acta Gastroenterol Latinoam 17:299-303
28. Lee JS, Oh TY, Kim YK, Baik JH, So S, Hahm KB, Surh YJ (2005) Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets. Mutat Res 579:214-224
29. Park S, Hahm KB, Oh TY, Jin JH, Choue R (2004) Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 49:384-394
30. Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ (2003) Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am J Physiol Gastrointest Liver Physiol 284:G321-G327
31. Ranford JC, Henderson B (2002) Chaperonins in disease: mechanisms, models, and treatments. Mol Pathol 55:209-213
32. Hartl FU, Hayer-Hartl M (2002) Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295:1852-1858
33. Nakamura K, Rokutan K, Marui N, Aoike A, Kawai K (1991) Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 101:161-166
34. Hirakawa T, Rokutan K, Nikawa T, Kishi K (1996) Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 111:345-357