Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells

Journal of Bone and Mineral Metabolism

Volumn 26, Issue 2, 2008, Pages 143-151

  Taketa, Tomonori ^a   Sakai, Akinori ^a   Tanaka, Shinya ^a   Nakai, Kenichiro ^a   Menuki, Kunitaka ^a   Yamane, Hirotoshi ^a   Tanaka, Kazuhiro ^a   Nakamura, Toshitaka ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Arthritis; Bone marrow; Cyclooxygenase; Osteoclast; RANKL

Indexed keywords

CELECOXIB; COLLAGEN; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; INTERLEUKIN 6; MESSENGER RNA; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SC 58560; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE ATROPHY; BONE MARROW CULTURE; BONE MASS; CONTROLLED STUDY; GENE EXPRESSION; HISTOPHOTOMETRY; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIUM; THERAPY EFFECT; TIBIA; TRABECULAR BONE; TREATMENT OUTCOME; TREATMENT RESPONSE;

AMINO ACIDS; ANIMALS; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL MARKERS; BODY WEIGHT; BONE AND BONES; BONE MARROW CELLS; CELLS, CULTURED; CYCLOOXYGENASE 2 INHIBITORS; GENE EXPRESSION REGULATION; INTERLEUKIN-6; MALE; MICE; ORGAN SIZE; OSTEOCALCIN; OSTEOPROTEGERIN; RANK LIGAND; RNA, MESSENGER; SYNOVIAL MEMBRANE; TIBIA;

EID: 39849096717     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-007-0808-2     Document Type: Article

References (36)