Two-stage designs for dose-finding trials with a biologic endpoint using stepwise tests

Biometrics

Volumn 64, Issue 1, 2008, Pages 232-241

  Polley, Mei Yin ^a   Cheung, Ying Kuen ^b  

^a AMGEN INC   (United States)

^b Columbia University ^*  (United States)

Author keywords

Familywise error rate; Futility interim; Minimum effective dose; Monotonicity; Multiple comparison; Probability of correct selection

Indexed keywords

DRUG DOSAGE;

DOSE FINDING; FAMILYWISE ERROR RATE; FUTILITY INTERIM; MINIMUM EFFECTIVE DOSE; MONOTONICITY; MULTIPLE COMPARISON; PROBABILITY OF CORRECT SELECTIONS; SAMPLE SIZES; STATINS; TWO STAGE DESIGNS;

GENE EXPRESSION;

CANCER; DISEASE; DRUG; GENE EXPRESSION;

ARTICLE; BIOLOGICAL ACTIVITY; BLOOD BRAIN BARRIER; CALIBRATION; DOSE CALCULATION; DOSE RESPONSE; DRUG ACTIVITY; GENE EXPRESSION; HODGKIN DISEASE;

EID: 39849090451     PISSN: 0006341X     EISSN: 15410420     Source Type: Journal    
DOI: 10.1111/j.1541-0420.2007.00827.x     Document Type: Article

References (14)