Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers

Biometrics

Volumn 64, Issue 1, 2008, Pages 299-308

  Zhou, Yinghui ^a   Whitehead, John ^a   Korhonen, Pasi ^b,c   Mustonen, Mika ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b ORION CORPORATION   (Finland)

^c StatFinn Oy   (Finland)

Author keywords

Bayesian decision procedure; Dose escalation; Healthy volunteer study; Phase I clinical trial; Simulation

Indexed keywords

MEDICAL APPLICATIONS;

BAYESIAN DECISION; BAYESIAN DECISION PROCEDURE; CLINICAL TRIAL; DECISION PROCEDURE; DOSE ESCALATION; HEALTHY VOLUNTEER STUDY; HEALTHY VOLUNTEERS; PHASE I; PHASE I CLINICAL TRIAL; SIMULATION;

PHARMACOKINETICS;

BAYESIAN ANALYSIS; DECISION MAKING; EXPERIMENTAL DESIGN; HEALTH WORKER;

AREA UNDER THE CURVE; ARTICLE; BAYES THEOREM; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG RESEARCH; DRUG SAFETY; HUMAN; SIMULATION;

EID: 39849090165     PISSN: 0006341X     EISSN: 15410420     Source Type: Journal    
DOI: 10.1111/j.1541-0420.2007.00841.x     Document Type: Article

References (18)