Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 83, Issue 1, 2008, Pages 1-11

  Gohlke, Julia M ^a,b   Griffith, William C ^a   Faustman, Elaine M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Apoptosis; Cell cycle; Cross species; Evolution; Mathematical model; Neocortex; Neuron number neurogenesis; Rhesus monkey

Indexed keywords

ALCOHOL;

APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL COUNT; CELL CYCLE; CELL POPULATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; EXPERIMENTAL STUDY; EXPOSURE; GROWTH INHIBITION; HUMAN; IN VIVO STUDY; MATHEMATICAL MODEL; NEOCORTEX; NERVE CELL; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PREDICTION; PRIMATE; PRIORITY JOURNAL; RAT; RHESUS MONKEY; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SPECIES COMPARISON; STEM CELL; SYNAPTOGENESIS; UTERUS;

ABNORMALITIES, DRUG-INDUCED; ADULT; ANIMALS; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; HUMANS; MACACA MULATTA; MICE; MODELS, NEUROLOGICAL; NEOCORTEX; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY; TERATOGENS;

MACACA MULATTA; PRIMATES; RATTUS; RODENTIA;

EID: 39849087727     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20137     Document Type: Article

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