Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc1 complex

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1777, Issue 3, 2008, Pages 239-249

  Rotsaert, Frederik A J ^a   Covian, Raul ^a   Trumpower, Bernard L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

bc1, complex; Cytochrome b; Kinetics; Protonmotive Q cycle; Yeast

Indexed keywords

CARBONYL DERIVATIVE; CYSTEINE; CYTOCHROME B; GLUTAMIC ACID; GLUTAMINE; HEME; HISTIDINE; METHIONINE; PROPIONIC ACID; QUINOLINIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRYPTOPHAN; UBIQUINOL CYTOCHROME C REDUCTASE;

AMINO ACID SUBSTITUTION; ARTICLE; ELECTRON TRANSPORT; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROGEN BOND; MUTATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; STEADY STATE; THERMODYNAMICS; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; CYTOCHROMES B; CYTOCHROMES C; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; HEME; KINETICS; LIGANDS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTON-MOTIVE FORCE; QUINONE REDUCTASES; THERMODYNAMICS; UBIQUINONE; YEASTS;

EID: 39849085524     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2007.08.005     Document Type: Article

References (28)

1. Trumpower B.L., and Gennis R.B. Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: the enzymology of coupling electron transfer reactions to transmembrane proton translocation. Annu. Rev. Biochem. 63 (1994) 675-716
2. Mitchell P. Possible molecular mechanisms of the protonmotive function of cytochrome systems. J. Theor. Biol. 62 (1976) 327-367
3. 1 complex dimer is reduced through center N. J. Biol. Chem. 280 (2005) 22732-22740
4. 1 complex. J. Biol. Chem. 279 (2004) 15040-15049
5. 1 complex: consequences for semiquinone stabilization. J. Biol. Chem 282 (2007) 24198-24208
6. 1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 8 (2000) 669-684
7. 1 complex in Saccharomyces cerevisiae with mutants resistant to ilicicolin H, a novel Qn site inhibitor. J. Biol. Chem. 281 (2006) 36036-36043
8. 1 complex. Biochim. Biophys. Acta 1275 (1996) 61-69
9. Coppee J.Y., Tokutake N., Marc D., di Rago J.P., Miyoshi H., and Colson A.M. Analysis of revertants from respiratory deficient mutants within the center N of cytochrome b in Saccharomyces cerevisiae. FEBS Lett. 339 (1994) 1-6
10. 1 complex in temperature-sensitive mutants of the cytochrome b gene, impaired in the catalytic center N. J. Biol. Chem. 270 (1995) 29356-29364
11. Trumpower B.L., and Edwards C.A. Purification of a reconstitutively active iron-sulfur protein (oxidation factor) from succinate. cytochrome c reductase complex of bovine heart mitochondria. J. Biol. Chem. 254 (1979) 8697-8706
12. Brasseur G., and Brivet-Chevillotte P. Characterization of mutations in the mitochondrial cytochrome b gene of Saccharomyces cerevisiae affecting the quinone reductase site (QN). Eur. J. Biochem. 230 (1995) 1118-1124
13. 1 complex. J. Biol. Chem. 274 (1999) 31209-31216
14. 1 complexes containing site-directed mutants of the Rieske iron-sulfur protein. Biochim. Biophys. Acta 1365 (1998) 125-134
15. 1. J. Biol. Chem. 247 (1972) 1012-1019
16. Berden J.A., and Slater E.C. The reaction of antimycin with a cytochrome b preparation active in reconstitution of the respiratory chain. Biochim. Biophys. Acta 216 (1970) 237-249
17. Dutton P.L. Redox potentiometry: determination of midpoint potentials of oxidation-reduction components of biological electron-transfer systems. Methods Enzymol. 54 (1978) 411-435
18. Lemesle-Meunier D., Brivet-Chevillotte P., di Rago J.P., Slonimski P.P., Bruel C., Tron T., and Forget N. Cytochrome b-deficient mutants of the ubiquinol-cytochrome c oxidoreductase in Saccharomyces cerevisiae. Consequence for the functional and structural characteristics of the complex. J. Biol. Chem. 268 (1993) 15626-15632
19. Esposti M.D., De Vries S., Crimi M., Ghelli A., Patarnello T., and Meyer A. Mitochondrial cytochrome b: evolution and structure of the protein. Biochim. Biophys. Acta 1143 (1993) 243-271
20. 1 complex. Science 281 (1998) 64-71
21. 1. Nature 392 (1998) 677-684
22. 1: comparison with its mitochondrial and chloroplast counterparts. Photosynth. Res. 81 (2004) 251-275
23. 1-site electron transfer inhibitors on the absorption spectra of mitochondrial cytochromes b. FEBS Lett. 181 (1985) 95-99
24. 1 complex. J. Biol. Chem. 279 (2004) 8708-8714
25. Safo M.K., Gupta G.P., Walker F.A., and Scheidt W.R. Models of the cytochromes b. Control of axial ligand orientation with a hindered porphyrin system. JACS 113 (1991) 5497-5500
26. Crofts A., Hacker B., Barquera B., Yun C.H., and Gennis R. Structure and function of the bc-complex of Rhodobacter sphaeroides. Biochim. Biophys. Acta 1101 (1992) 162-165
27. 1 complex. Biochemistry 44 (2005) 10520-10532
28. Shinkarev V.P. Ubiquinone (coenzyme Q10) binding sites: low dielectric constant of the gate prevents the escape of the semiquinone. FEBS Lett. 580 (2006) 2534-2539