The interdependence between catalytic activity, conformational stability, and cytotoxicity of onconase

Cancer Biology and Therapy

Volumn 6, Issue 8, 2007, Pages 1244-1250

  Schulenburg, Cindy ^a   Ardelt, Barbara ^b   Ardelt, Wojciech ^b   Arnold, Ulrich ^a   Shogen, Kuslima ^b   Ulbrich Hofmann, Renate ^a   Darzynkiewicz, Zbigniew ^c  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b Alfacell Corporation   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Cancer cell lines; Catalytic activity; Cytotoxicity; Flow cytometry; Genetic engineering; Growth inhibition assays; Onconase; Stability

Indexed keywords

RANPIRNASE; RIBONUCLEOPROTEIN; ANTINEOPLASTIC AGENT; RIBONUCLEASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CATALYSIS; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CLONOGENESIS; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DRUG CONFORMATION; DRUG STABILITY; FROG; GENE MUTATION; HUMAN; HUMAN CELL; MALIGNANT MESOTHELIOMA; MESOTHELIOMA; SITE DIRECTED MUTAGENESIS; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ENZYME STABILITY; FLOW CYTOMETRY; GENETICS; IC 50; PROTEIN CONFORMATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENZYME STABILITY; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN CONFORMATION; RIBONUCLEASES;

EID: 39749196230     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.8.4423     Document Type: Article

References (41)