Adverse events associated with chlorhexidine use: Results from the Department of Veterans Affairs Dental Diabetes Study

Journal of the American Dental Association

Volumn 139, Issue 2, 2008, Pages 178-183

  McCoy, Linda C ^a   Wehler, Carolyn J ^b   Rich, Sharron E ^b   Garcia, Raul I ^b,c   Miller, Donald R ^b,d   Jones, Judith A ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY   (United States)

^c VA BOSTON HEALTHCARE SYSTEM   (United States)

^d Center for Health Quality Outcomes and Economic Research   (United States)

Author keywords

Chlorhexidine gluconate; Diabetes; Mouthrinse; Periodontal disease

Indexed keywords

EID: 39749191916     PISSN: 00028177     EISSN: None     Source Type: Journal    
DOI: 10.14219/jada.archive.2008.0134     Document Type: Article

References (32)

1. Fardai O, Turnbull RS. A review of the literature on use of Chlorhexidine in dentistry. JADA 1986;112(6):863-9.
2. Jones CG. Chlorhexidine: is it still the gold standard? Periodontal 2000 1997;15:55-62.
3. Killoy W. The use of locally delivered Chlorhexidine in the treatment of periodontitis: clinical results. J Clin Periodontol 1998;25(11 part 2):953-8.
4. Lite H, Schiott CR. The effect of mouthrinses and topical application of Chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res 1970;5(2):79-83.
5. Flotra L, Gjermo P, Rolla G, Waerhaug J. Side effects of Chlorhexidine mouth washes. Scand J Dent Res 1971;79(2):119-25.
6. Yaacob H, Jalil R. An unusual hypersensitivity reaction to Chlorhexidine. J Oral Med 1986;41(3):145-6.
7. Addy M, Moran JM. Clinical indications for the use of chemical adjuncts to plaque control: Chlorhexidine formulations. Periodontol 2000 1997;15:52-4.
8. Albandar J, Gjermo P, Preus HR. Chlorhexidine use after two decades of over-the-counter availability. J Periodontol 1994;65(2): 109-12.
9. Grossman E, Reiter G, Sturzenberger O, et al. Six-month study of the effects of a Chlorhexidine mouthrinse on gingivitis in adults. J Periodontal Res 1986;21(supplement):33-43.
10. Siegrist B, Gusberti F, Brecx M, Weber H, Lang N. Efficacy of supervised rinsing with Chlorhexidine digluconate in comparison to phenolic and plant alkaloid compounds. J Periodontal Res 1986;21 (supplement):60-73.
11. al-Tannir MA, Goodman HS. A review of Chlorhexidine and its use in special populations. Spec Care Dentist 1994;14(3):116-22.
12. Ashoe-Jorgensen V, Attstrom R, Lang N, Loe H. Effect of Chlorhexidine dressing on healing after periodontal surgery. J Dent Resh 1972;51(supplement5): 314.
13. Beiswanger BB, Mallat ME, Jackson RD, et al. Clinical effects of 0.12% Chlorhexidine rinse as an adjunct to scaling and root planing. J Clin Dent 1992;3(2):33-8.
14. Jenatschke F, Elsenberger E, Weite HD, Schlagenhauf U. Influence of repeated Chlorhexidine varnish applications on mutans streptococci counts and caries increment in patients treated with fixed orthodontic appliances. J Orofac Orthop 2001;62(1):36-45.
15. Flotra L. Different modes of Chlorhexidine application and related local side effects. J Periodontal Res Suppl 1973;12:41-4.
16. Ciancio SG. Chemotherapeutics in periodontics. Dent Clin North Am 1980;24(4):813-26.
17. Hamill MB, Osato MS, Wilhelmus KR. Experimental evaluation of Chlorhexidine gluconate for ocular antisepsis. Antimicrob Agents Chemother 1984;26(6):793-6.
18. Bendig JW. Surgical hand disinfection: comparison of 4% Chlorhexidine detergent solution and 2% triclosan detergent solution. J Hosp Infect 1990;15(2):143-8.
19. Rosenberg A, Alatary SD, Peterson AF. Safety and efficacy of the antiseptic Chlorhexidine gluconate. Surg Gynecol Obstet 1976;143(5):789-92.
20. Jones JA, Miller DR, Wehler CJ, et al. Study design, recruitment, and baseline characteristics: the Department of Veterans Affairs Dental Diabetes Study. J Clin Periodontol 2007;34(1):40-5.
21. Cutress TW, Ainamo J, Sardo-Infirri J. The community periodontal index of treatment needs (CPITN) procedure for population groups and individuals. Int Dent J 1987;37(4):222-33.
22. Jones JA, Miller DR, Wehler CJ, et al. Does periodontal care improve glycemic control? The Department of Veterans Affairs Dental Diabetes Study. J Clin Periodontol 2007;34(1);46-52.
23. International classification of diseases, 9th revision, clinical modification. 5th ed. Salt Lake City: Medicode; 1996.
24. Selim AJ, Fincke G, Ren XS, et al. Comorbidity assessments based on patient report: results from the Veterans Health Study. J Ambul Care Manage 2004;27(3):281-95.
25. Fincke BG, Clark JA, Linzer M, Spiro A 3rd, et al. Assessment of long-term complications due to type 2 diabetes using patient selfreport: the diabetes complications index. J Ambul Care Manage 2005;28(3):262-73.
26. U.S. Department of Veterans Affairs. Reporting unanticipated problems and adverse events to institutional review boards; 2006. Available at: "www1.va.gov/oro/docs/Memo-UPR-AERpts-12-06-06.rtf. Accessed Jan. 7, 2008.
27. Atchison KA, Dolan TA. Development of the Geriatric Oral Health Assessment Index. J Dent Educ 1990;54(11):680-7.
28. Löe H, Schiott CR, Karring G, Karring T. Two years oral use of Chlorhexidine in man, I: general design and clinical effects. J Periodontal Res 1976;11(3):135-44.
29. Lang NP, Hase JC, Grassi M, et al. Plaque formation and gingivitis after supervised mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% Chlorhexidine digluconate and placebo for 6 months. Oral Dis 1998;4(2):105-13.
30. Hase JC, Attstrom R, Edwardsson S, Kelty E, Kisch J. 6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% Chlorhexidine digluconate and placebo, I: effect on plaque formation and gingivitis. J Clin Periodontol 1998;25(9):746-53.
31. Ernst CP, Prockl K, Willershausen B. The effectiveness and side effects of 0.1% and 0.2% Chlorhexidine mouthrinses: a clinical study. Quintessence Int 1998;29(7):443-8.
32. United States Department of Veterans Affairs. VA Programs for women veterans: demographic trends; 2007. Available at: "wwwl. va.gov/wvhp/page.cfm?pg=26". Accessed Dec. 12, 2007.