Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline- 4(3H),4′-piperidin]-3-ones as nociceptin receptor agonists

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 1058-1062

  Mustazza, Carlo ^a   Borioni, Anna ^a   Sestili, Isabella ^a   Sbraccia, Maria ^a   Rodomonte, Andrea ^a   Del Giudice, Maria Rosaria ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDROSPIRO[ISOQUINOLINE 4(3H) 4' PIPERIDIN ] 3 ONE; GUANOSINE TRIPHOSPHATE; LIGAND; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RECEPTOR AFFINITY; RECEPTOR BINDING;

CELL LINE; CYCLOHEXANES; HUMANS; ISOQUINOLINES; MODELS, MOLECULAR; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39749191240     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7009606     Document Type: Article

References (24)