Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors: Part I - Discovery of two binding modes

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 725-736

  Zhu, Zhaoning ^a   Mazzola, Robert ^a   Sinning, Lisa ^a   McKittrick, Brian ^a   Niu, Xiaoda ^a   Lundell, Daniel ^a   Sun, Jing ^a   Orth, Peter ^a   Guo, Zhuyan ^a   Madison, Vincent ^a   Ingram, Richard ^a   Beyer, Brian M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (2 METHYLQUINOLIN 4 YL)METHOXYLPHENYL] 2 TRANS CARBOMETHOXYLCYCLOPROPANE HYDROXYAMIC ACID; 2 [3 (3,4 DICHLOROBENZYLOXY)PHENYL] 2 TRANS CARBOMETHOXYLCYCLOPROPANE HYDROXYAMIC ACID; 2 CARBOISOPROPOXYL 2 [3 (2 METHYLQUINOLIN 4 YL)METHOXYLPHENYL]CYCLOPROPANE HYDROXYAMIC ACID; HYDROXAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ADAM PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HYDROXAMIC ACIDS; MODELS, MOLECULAR; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39749190017     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070376o     Document Type: Article

References (45)