Spindle position assessment prior to ICSI does not benefit fertilization or early embryo quality

Reproductive BioMedicine Online

Volumn 16, Issue 2, 2008, Pages 232-238

  Woodward, Bryan J ^a   Montgomery, Sue J ^b   Hartshorne, Geraldine M ^b   Campbell, Keith H S ^a   Kennedy, Richard ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

Author keywords

Embryo; Human; ICSI; Oocyte; Polarized light microscope; Spindle

Indexed keywords

ADULT; ARTICLE; EMBRYO DEVELOPMENT; FEMALE; FERTILIZATION; HUMAN; HUMAN CELL; IMAGING; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MITOSIS SPINDLE; NON INVASIVE PROCEDURE; OOCYTE DONATION; OUTCOME ASSESSMENT; POLARIZATION MICROSCOPE;

EID: 39749183645     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)60579-2     Document Type: Article

References (19)

1. Blake M, Garrisi J, Tomkin G et al. 2000 Sperm deposition site during ICSI affects fertilization and development. Fertility and Sterility 73, 31-37.
2. Cohen Y, Malcov M, Schwartz T et al. 2004 Spindle imaging: a new marker for optimal timing of ICSI? Human Reproduction 19, 649-654.
3. Cooke S, Tyler JP, Driscoll GL 2003 Meiotic spindle location and identification and its effect on embryonic cleavage plane and early development. Human Reproduction 18, 2397-2405.
4. Garello C, Baker H, Rai J et al. 1999 Pronuclear orientation, polar body placement, and embryo quality after intracytoplasmic sperm injection and in-vitro fertilization: further evidence for polarity in human oocytes? Human Reproduction 14, 2588-2595.
5. Hamberger L, Hardarson T, Nygren KG 2005 Avoidance of multiple pregnancy by use of single embryo transfer. Minerva Ginecologica 57, 15-19.
6. Lanzendorf S, Maloney M, Ackerman S et al. 1988 Fertilizing potential of acrosome-defective sperm following microsurgical injection into eggs. Gamete Research 19, 329-337.
7. Liu L, Trimarchi JR, Oldenbourg R et al. 2000 increased birefringence in the meiotic spindle provides a new marker for the onset of activation in living oocytes. Biology of Reproduction 63, 251-258.
8. Montag M, Schimming T, van der Ven H 2006 Spindle imaging in human oocytes: the impact of the meiotic cell cycle. Reproductive BioMedicine Online 12, 442-446.
9. Moon JH, Hyun CS, Lee SW et al. 2003 Visualization of the metaphase II meiotic spindle in living human oocytes using the PolScope enables the prediction of embryonic developmental competence after ICSI. Human Reproduction 18, 817-820.
10. Nagy ZP, Liu J, Joris H et al. 1995 The influence of the site of sperm deposition and mode of oolemma breakage at intracytoplasmic sperm injection on fertilization and embryo development rates. Human Reproduction 10, 3171-3177.
11. Richter KS, Davis A, Carter J et al. 2006 No advantage of laser-assisted over conventional intracytoplasmic sperm injection: a randomized controlled trial. Journal of Experimental and Clinical Assisted Reproduction 5, 3-5.
12. Rienzi L, Martinez F, Ubaldi F et al. 2004 PolScope analysis of meiotic spindle changes in living metaphase II human oocytes during the freezing and thawing procedures. Human Reproduction 19, 655-659.
13. Rienzi L, Ubaldi F, Martinez F et al. 2003 Relationship between meiotic spindle location with regard to the polar body position and oocyte developmental potential after ICSI. Human Reproduction 18, 1289-1293.
14. Scott LA 2000 Oocyte and embryo polarity. Seminars in Reproductive Medicine 18, 171-183.
15. Steuerwald NM 2007 Maternal age-related differential global expression profiles observed in human oocytes. Reproductive BioMedicine Online 14, 700-708.
16. Stoddart NR, Fleming SD 2000 Orientation of the first polar body of the oocyte at 6 or 12 o'clock during ICSI does not affect clinical outcome. Human Reproduction 15, 1580-1585.
17. Van der Westerlaken LA, Helmerhorst FM, Hermans J et al. 1999 Intracytoplasmic sperm injection: position of the polar body affects pregnancy rate. Human Reproduction 14, 2565-2569.
18. Van Steirteghem AC, Nagy Z, Joris H et al. 1993 High fertilization and implantation rates after intracytoplasmic sperm injection. Human Reproduction 8, 1061-1066.
19. Wang WH, Meng L, Hackett RJ et al. 2001 The spindle observation and its relationship with fertilization after intracytoplasmic sperm injection in living human oocytes. Fertility and Sterility 75, 348-353.