Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis

Arthritis and Rheumatism

Volumn 58, Issue 2, 2008, Pages 547-555

  Elst, Elisabeth F ^a,b   Klein, Mark ^a,b   De Jager, Wilco ^a,b   Kamphuis, Sylvia ^c   Wedderburn, Lucy R ^d   Van Der Zee, Ruurd ^e   Albani, Salvatore ^b,f   Kuis, Wietse ^a,b   Prakken, Berent J ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b EUREKA Institute for Translational Medicine   (Italy)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UTRECHT UNIVERSITY   (Netherlands)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CYTOKINE; HEAT SHOCK PROTEIN 60; INTERLEUKIN 10; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL SPECIFICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOMYOSITIS; DISEASE ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREGULATION; JUVENILE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MUSCLE BIOPSY; MUSCLE CELL; MUSCLE TISSUE; MYOSITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN INDUCTION; PROTEIN TARGETING; REGULATORY T LYMPHOCYTE; REMISSION; SCHOOL CHILD; T LYMPHOCYTE; UPREGULATION;

AUTOANTIGENS; BIOPSY; CHAPERONIN 60; CHILD; CYTOKINES; DERMATOMYOSITIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MALE; MUSCLE, SKELETAL; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

EID: 39749174968     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23202     Document Type: Article

References (28)

1. Pachman LM. Juvenile dermatomyositis: immunogenetics, pathophysiology, and disease expression. Rheum Dis Clin North Am 2002;28:579-602, vii.
2. Pilkington CA, Wedderburn LR. Paediatric idiopathic inflammatory muscle disease: recognition and management. Drugs 2005;65:1355-65.
3. Nagaraju K. Update on immunopathogenesis in inflammatory myopathies. Curr Opin Rheumatol 2001;13:461-8.
4. Casciola-Rosen L, Nagaraju K, Plotz P, Wang K, Levine S, Gabrielson E, et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005;201:591-601.
5. Koffeman EC, Prakken B, Albani S. Recent developments in immunomodulatory peptides in juvenile rheumatic diseases: from trigger to dimmer? Curr Opin Rheumatol 2005;17:600-5.
6. Pockley AG. Heat shock proteins as regulators of the immune response. Lancet 2003;362:469-76.
7. Van Eden W, van der Zee R, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 2005;5:318-30.
8. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002;2:185-94.
9. Van Eden W, Thole JE, van der Zee R, Noordzij A, van Embden JD, Hensen EJ, et al. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 1988;331:171-3.
10. Ramage JM, Gaston JS. Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60. Rheumatology (Oxford) 1999;38:631-5.
11. Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR. T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. J Autoimmun 1999;12:121-9.
12. Bason C, Corrocher R, Lunardi C, Puccetti P, Olivieri O, Girelli D, et al. Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis. Lancet 2003;362:1971-7.
13. De Graeff-Meeder ER, van der Zee R, Rijkers GT, Schuurman HJ, Kuis W, Bijlsma JW, et al. Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis. Lancet 1991;337:1368-72.
14. Prakken AB, van Eden W, Rijkers GT, Kuis W, Toebes EA, de Graeff-Meeder ER, et al. Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:1826-32.
15. Kamphuis S, Kuis W, de Jager W, Teklenburg G, Massa M, Gordon G, et al. Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet 2005;366:50-6.
16. Liu Y, Steinacker JM. Changes in skeletal muscle heat shock proteins: pathological significance. Front Biosci 2001;6:D12-25.
17. Samelman TR. Heat shock protein expression is increased in cardiac and skeletal muscles of Fischer 344 rats after endurance training. Exp Physiol 2000;85:92-102.
18. Khassaf M, Child RB, McArdle A, Brodie DA, Esanu C, Jackson MJ. Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise. J Appl Physiol 2001;90:1031-5.
19. Giannessi D, Caselli C, Vitale RL, Crucean A, Murzi B, Ry SD, et al. A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients. Pharmacol Res 2003;48:519-29.
20. Hohlfeld R, Engel AG. Expression of 65-kd heat shock proteins in the inflammatory myopathies. Ann Neurol 1992;32:821-3.
21. Tezak Z, Hoffman EP, Lutz JL, Fedczyna TO, Stephan D, Bremer EG, et al. Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis. J Immunol 2002;168:4154-63.
22. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts), N Engl J Med 1975;292:344-7.
23. Lovell DJ, Lindsley CB, Rennebohm RM, Ballinger SH, Bowyer SL, Giannini EH, et al, in cooperation with the Juvenile Dermatomyositis Disease Activity Collaborative Study Group. Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies. II. The Childhood Myositis Assessment Scale (CMAS): a quantitative tool for the evaluation of muscle function. Arthritis Rheum 1999;42:2213-9.
24. Nascif AK, Terreri MT, Len CA, Andrade LE, Hilario MO. Inflammatory myopathies in childhood: correlation between nailfold capillaroscopy findings and clinical and laboratory data. J Pediatr (Rio J) 2006;82:40-5.
25. Van den Broek MF, Hogervorst EJ, Van Bruggen MC, van Eden W, van der Zee R, van den Berg WB. Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein. J Exp Med 1989;170:449-66.
26. Vignali DA. Multiplexed particle-based flow cytometric assays. J Immunol Methods 2000;243:243-55.
27. De Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003;10:133-9.
28. Massa M, Costouros N, Mazzoli F, De Benedetti F, La Cava A, Le T, et al. Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis. Arthritis Rheum 2002;46:3015-25.