메뉴 건너뛰기




Volumn 26, Issue 6, 2008, Pages 942-947

Full-dose gemcitabine with concurrent radiation therapy in patients with nonmetastatic pancreatic cancer: A multicenter phase II trial

Author keywords

[No Author keywords available]

Indexed keywords

CA 19-9 ANTIGEN; GEMCITABINE; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG DERIVATIVE; TUMOR MARKER;

EID: 39749174027     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2007.13.9014     Document Type: Article
Times cited : (143)

References (38)
  • 1
    • 0032794456 scopus 로고    scopus 로고
    • Studies of intraoperative radiotherapy in carcinoma of the pancreas
    • suppl
    • Sindelar WF, Kinsella TJ: Studies of intraoperative radiotherapy in carcinoma of the pancreas. Ann Oncol 10:226-230, 1999 (suppl)
    • (1999) Ann Oncol , vol.10 , pp. 226-230
    • Sindelar, W.F.1    Kinsella, T.J.2
  • 2
    • 0018841688 scopus 로고
    • Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma: A comparative study to surgical resection
    • Shipley WU, Nardi GL, Cohen AM, et al: Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma: A comparative study to surgical resection. Cancer 45:709-714, 1980
    • (1980) Cancer , vol.45 , pp. 709-714
    • Shipley, W.U.1    Nardi, G.L.2    Cohen, A.M.3
  • 3
    • 0023856763 scopus 로고
    • Combined modality treatment of localized unresectable adenocarcinoma of the pancreas
    • Mohiuddin M, Cantor RJ, Biermann W et al: Combined modality treatment of localized unresectable adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 14:79-84, 1988
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 79-84
    • Mohiuddin, M.1    Cantor, R.J.2    Biermann, W.3
  • 4
    • 0003288820 scopus 로고    scopus 로고
    • A phase II trial of continuous infusion (CIVI) 5-FU with 3-D conformal radiation in the adjuvant treatment of pancreatic, ampullary and biliary cancers
    • abstr 1023
    • Picus J, Myerson R, Drebin J, et al: A phase II trial of continuous infusion (CIVI) 5-FU with 3-D conformal radiation in the adjuvant treatment of pancreatic, ampullary and biliary cancers. Proc Am Soc Clin Oncol 6:16, 1998 (abstr 1023)
    • (1998) Proc Am Soc Clin Oncol , vol.6 , pp. 16
    • Picus, J.1    Myerson, R.2    Drebin, J.3
  • 5
    • 2442593990 scopus 로고    scopus 로고
    • Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: Toxicity and clinical outcome
    • Milano MT, Chumra SJ, Garafalo MC, et al: Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: Toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 59:445-453, 2004
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 445-453
    • Milano, M.T.1    Chumra, S.J.2    Garafalo, M.C.3
  • 6
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA, Moore MJ, Andersen J, et al: Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15:2403-2413, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 7
    • 0030005273 scopus 로고    scopus 로고
    • Radiosensitization of pancreatic cancer cells by 2-,2-difluor-2-deoxycitadine
    • Lawrence TS, Chang EY, Hahn TM, et al: Radiosensitization of pancreatic cancer cells by 2-,2-difluor-2-deoxycitadine. Int J Radiat Oncol Biol 34:867-872, 1996
    • (1996) Int J Radiat Oncol Biol , vol.34 , pp. 867-872
    • Lawrence, T.S.1    Chang, E.Y.2    Hahn, T.M.3
  • 8
    • 0033022613 scopus 로고    scopus 로고
    • Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancer
    • Blackstock AW, Bernard SA, Richards F, et al: Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancer. J Clin Oncol 17:2208-2212, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 2208-2212
    • Blackstock, A.W.1    Bernard, S.A.2    Richards, F.3
  • 9
    • 0034306137 scopus 로고    scopus 로고
    • Eastern Cooperative Oncology Group phase I trial of protracted venous infusion fluorouracil plus weekly gemcitabine with concurrent radiation therapy in patients with locally advanced pancreas cancer: A regimen with unexpected early toxicity
    • Talamonti MS, Catalano PJ, Vaughn DJ, et al: Eastern Cooperative Oncology Group phase I trial of protracted venous infusion fluorouracil plus weekly gemcitabine with concurrent radiation therapy in patients with locally advanced pancreas cancer: A regimen with unexpected early toxicity. J Clin Oncol 18:3384-3389, 2000
    • (2000) J Clin Oncol , vol.18 , pp. 3384-3389
    • Talamonti, M.S.1    Catalano, P.J.2    Vaughn, D.J.3
  • 10
    • 0034880820 scopus 로고    scopus 로고
    • Phase I trial of gemcitabine combined with radiation for the treatment of locally advanced pancreatic adenocarcinoma
    • Wolff RA, Evans DB, Gravel DM, et al: Phase I trial of gemcitabine combined with radiation for the treatment of locally advanced pancreatic adenocarcinoma. Clin Cancer Res 7:2246-2253, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 2246-2253
    • Wolff, R.A.1    Evans, D.B.2    Gravel, D.M.3
  • 11
    • 0035890443 scopus 로고    scopus 로고
    • Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer
    • McGinn CJ, Zalupski MM, Shureiqi I, et al: Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 19:4202-4208, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 4202-4208
    • McGinn, C.J.1    Zalupski, M.M.2    Shureiqi, I.3
  • 12
    • 31544438080 scopus 로고    scopus 로고
    • A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma
    • Talamonti MS, Small W, Mulcahy MF, et al: A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma. Ann Surg Oncol 13:150-158, 2006
    • (2006) Ann Surg Oncol , vol.13 , pp. 150-158
    • Talamonti, M.S.1    Small, W.2    Mulcahy, M.F.3
  • 13
    • 35348876350 scopus 로고    scopus 로고
    • Time, dose, and fractionation in radiotherapy
    • Hall EJ:, Philadelphia, PA, Lippincott, Williams & Wilkins
    • Hall EJ, Giaccia AJ: Time, dose, and fractionation in radiotherapy, in Hall EJ: Radiobiology for the Radiologist. Philadelphia, PA, Lippincott, Williams & Wilkins, 2006, pp 378-397
    • (2006) Radiobiology for the Radiologist , pp. 378-397
    • Hall, E.J.1    Giaccia, A.J.2
  • 14
    • 84871470681 scopus 로고    scopus 로고
    • National Cancer Institute Common Toxicity Criteria Version 2.0
    • National Cancer Institute Common Toxicity Criteria Version 2.0. http://ctep.cancer.gov/forms/CTCv20_4-30-992.pdf
  • 16
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck S, Eisenhauer E, et al: New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205-216, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.2    Eisenhauer, E.3
  • 17
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II trials
    • Simon R: Optimal two-stage designs for phase II trials. Control Clin Trials 10:1-10, 1989
    • (1989) Control Clin Trials , vol.10 , pp. 1-10
    • Simon, R.1
  • 18
    • 33845382806 scopus 로고
    • Nonparametric estimation of incomplete observations
    • Kaplan E, Meier P: Nonparametric estimation of incomplete observations. J Am Stat Assoc 53:457-481, 1958
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 19
    • 40849129579 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiation for pancreatic cancer
    • June
    • Moessinger RC: Neoadjuvant chemoradiation for pancreatic cancer. US Oncological Disease 51-52, 2006 (June)
    • (2006) US Oncological Disease , pp. 51-52
    • Moessinger, R.C.1
  • 20
    • 23644445319 scopus 로고    scopus 로고
    • Serum CA 19-9 response as a surrogate for clinical outcome in patients receiving fixed-dose rate gemcitabine for advanced pancreatic cancer
    • Ko AH, Hwang J, Venook AP, et al: Serum CA 19-9 response as a surrogate for clinical outcome in patients receiving fixed-dose rate gemcitabine for advanced pancreatic cancer. Br J Cancer 93:195-199, 2005
    • (2005) Br J Cancer , vol.93 , pp. 195-199
    • Ko, A.H.1    Hwang, J.2    Venook, A.P.3
  • 21
    • 40849112497 scopus 로고    scopus 로고
    • CA 19-9 level predicts response to GTX chemotherapy in pancreatic cancer
    • suppl; abstr 4206
    • Fogelman DR, Schreibman SM, Fine RL: CA 19-9 level predicts response to GTX chemotherapy in pancreatic cancer. J Clin Oncol 23:16S, 2005 (suppl; abstr 4206)
    • (2005) J Clin Oncol , vol.23
    • Fogelman, D.R.1    Schreibman, S.M.2    Fine, R.L.3
  • 22
    • 33846649482 scopus 로고    scopus 로고
    • Assessing prognosis in metastatic pancreatic cancer by the serum tumor marker CA 19-9: Pretreatment levels or kinetics during chemotherapy?
    • Boeck S, Schulz C, Stieber P, et al: Assessing prognosis in metastatic pancreatic cancer by the serum tumor marker CA 19-9: Pretreatment levels or kinetics during chemotherapy? Onkologie 30:39-42, 2007
    • (2007) Onkologie , vol.30 , pp. 39-42
    • Boeck, S.1    Schulz, C.2    Stieber, P.3
  • 23
    • 0034009704 scopus 로고    scopus 로고
    • Decrease of CA 19-9 during chemotherapy with gemcitabine predicts survival time in patients with advanced pancreatic cancer
    • Halm U, Schumann T, Schiefke I, et al: Decrease of CA 19-9 during chemotherapy with gemcitabine predicts survival time in patients with advanced pancreatic cancer. Br J Cancer 82:1013-1016, 2000
    • (2000) Br J Cancer , vol.82 , pp. 1013-1016
    • Halm, U.1    Schumann, T.2    Schiefke, I.3
  • 24
    • 0019410935 scopus 로고
    • Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil - The Gastrointestinal Tumor Study Group
    • Moertel CG, Frytak S, Hahn RG, et al: Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil - The Gastrointestinal Tumor Study Group. Cancer 48:1705-1710, 1981
    • (1981) Cancer , vol.48 , pp. 1705-1710
    • Moertel, C.G.1    Frytak, S.2    Hahn, R.G.3
  • 25
    • 0023722682 scopus 로고
    • Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group: Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 80:751-755, 1988
    • (1988) J Natl Cancer Inst , vol.80 , pp. 751-755
  • 26
    • 0023262033 scopus 로고
    • Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group: Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006-2010, 1987
    • (1987) Cancer , vol.59 , pp. 2006-2010
  • 27
    • 0021867923 scopus 로고
    • Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection
    • Kalser MH, Ellenberg SS: Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120:899-903, 1985
    • (1985) Arch Surg , vol.120 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 28
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5-fluorouracil after curative resection of the pancreas and periampullary region: Phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group (with discussion)
    • Klinkenbijl JH, Jeekel J, Sahmoud T, et al: Adjuvant radiotherapy and 5-fluorouracil after curative resection of the pancreas and periampullary region: Phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group (with discussion). Ann Surg 230:776-784, 1999
    • (1999) Ann Surg , vol.230 , pp. 776-784
    • Klinkenbijl, J.H.1    Jeekel, J.2    Sahmoud, T.3
  • 29
    • 84871468439 scopus 로고    scopus 로고
    • ESPAC-1: Final results of a European, randomised controlled trial to assess the roles of adjuvant chemotherapy and adjuvant chemoradiation in resectable pancreatic cancer
    • Neoptolemos JP, Stocken DD, Friess H, et al: ESPAC-1: Final results of a European, randomised controlled trial to assess the roles of adjuvant chemotherapy and adjuvant chemoradiation in resectable pancreatic cancer. Pancreatology 3:209-269, 2003
    • (2003) Pancreatology , vol.3 , pp. 209-269
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3
  • 30
    • 3042697976 scopus 로고    scopus 로고
    • Chemotherapy for pancreatic cancer: Correspondence to the Editor
    • Crane CH, Ben-Josef E, Small W: Chemotherapy for pancreatic cancer: Correspondence to the Editor. N Engl J Med 350:2713-2715, 2004
    • (2004) N Engl J Med , vol.350 , pp. 2713-2715
    • Crane, C.H.1    Ben-Josef, E.2    Small, W.3
  • 31
    • 33746149215 scopus 로고    scopus 로고
    • RTOG 9704: A phase III study of adjuvant and post chemoradiation (CRT) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma
    • suppl; abstr 4007
    • Regine WF, Winter KW, Abrams R, et al: RTOG 9704: a phase III study of adjuvant and post chemoradiation (CRT) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma. J Clin Oncol 24:18S, 2006 (suppl; abstr 4007)
    • (2006) J Clin Oncol , vol.24
    • Regine, W.F.1    Winter, K.W.2    Abrams, R.3
  • 32
    • 33846405332 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer
    • Oettle H, Post S, Neuhaus P, et al: Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer. JAMA 297:267-277, 2007
    • (2007) JAMA , vol.297 , pp. 267-277
    • Oettle, H.1    Post, S.2    Neuhaus, P.3
  • 33
    • 0031056942 scopus 로고    scopus 로고
    • Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticduodenectomy for adenocarcinoma of the pancreas
    • Spitz FR, Abbruzzese JL, Lee JE, et al: Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 15:928-937, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 928-937
    • Spitz, F.R.1    Abbruzzese, J.L.2    Lee, J.E.3
  • 34
    • 0032421150 scopus 로고    scopus 로고
    • Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma
    • Pisters PWT, Abbruzzese JL, Janjan NA, et al: Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J Clin Oncol 16:3843-3850, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 3843-3850
    • Pisters, P.W.T.1    Abbruzzese, J.L.2    Janjan, N.A.3
  • 35
    • 0035093234 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: Treatment variables and survival duration
    • Breslin TM, Hess KR, Harbison DB, et al: Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: Treatment variables and survival duration. Ann Surg Oncol 8:123-132, 2001
    • (2001) Ann Surg Oncol , vol.8 , pp. 123-132
    • Breslin, T.M.1    Hess, K.R.2    Harbison, D.B.3
  • 36
    • 0036549518 scopus 로고    scopus 로고
    • Preoperative chemoradiation in the management of adenocarcinoma of the body of pancreas
    • Arnoletti P, Hoffman J, Ross EA, et al: Preoperative chemoradiation in the management of adenocarcinoma of the body of pancreas. Am Surg 68:330-335, 2002
    • (2002) Am Surg , vol.68 , pp. 330-335
    • Arnoletti, P.1    Hoffman, J.2    Ross, E.A.3
  • 37
    • 33746159832 scopus 로고    scopus 로고
    • Phase III trial comparing chemoradiotherapy (intermittent cisplatin and infusional 5-FU) followed by gemcitabine vs. gemcitabine alone in patients with locally advanced non metastatic pancreatic cancer: A FFCD-SFRO study
    • suppl; abstr 4008
    • Chauffert B, Mornex F, Bonnetain F, et al: Phase III trial comparing chemoradiotherapy (intermittent cisplatin and infusional 5-FU) followed by gemcitabine vs. gemcitabine alone in patients with locally advanced non metastatic pancreatic cancer: A FFCD-SFRO study. J Clin Oncol 24:18S, 2006 (suppl; abstr 4008)
    • (2006) J Clin Oncol , vol.24
    • Chauffert, B.1    Mornex, F.2    Bonnetain, F.3
  • 38
    • 34249332089 scopus 로고    scopus 로고
    • Full-dose gemcitabine and concurrent radiotherapy for unresectable pancreatic cancer
    • Murphy JD, Adusumilli S, Griffith KA, et al: Full-dose gemcitabine and concurrent radiotherapy for unresectable pancreatic cancer. Int J Rad Onc Biol Phys 68:801-808, 2007
    • (2007) Int J Rad Onc Biol Phys , vol.68 , pp. 801-808
    • Murphy, J.D.1    Adusumilli, S.2    Griffith, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.