Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin® given intravesically

Rapid Communications in Mass Spectrometry

Volumn 22, Issue 4, 2008, Pages 462-470

  Vainchtein, Liia D ^a,d   Rosing, Hilde ^a   Mirejovsky, Dorla ^b   Huynh, Van ^b   Lenaz, Luigi ^b   Schellens, Jan H M ^a,c   Beijnen, Jos H ^a,c  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b Spectrum Pharmaceuticals   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

^d SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APAZIQUONE; AZIRIDINE DERIVATIVE; EO 5A; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BLOOD; BLOOD ANALYSIS; CHEMISTRY; DOG; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; HUMAN; INTRAVESICAL DRUG ADMINISTRATION; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADMINISTRATION, INTRAVESICAL; ANIMALS; ANTINEOPLASTIC AGENTS; AZIRIDINES; BLOOD CHEMICAL ANALYSIS; DOGS; DRUG EVALUATION; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLEQUINONES; MICROCHEMISTRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 39749173791     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.3387     Document Type: Article

References (20)