Synthesis and antitumor evaluation of bis aza-anthracene-9,10-diones and bis aza-anthrapyrazole-6-ones

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 997-1006

  Antonini, Ippolito ^a   Santoni, Giorgio ^a   Lucciarini, Roberta ^a   Amantini, Consuelo ^a   Dal Ben, Diego ^a   Volpini, Rosaria ^a   Cristalli, Gloria ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,9 BIS[2 [2 (DIETHYLAMINO)ETHYL] 6 OXO 2,6 DIHYDROINDAZOLO[3,4 FG]ISOQUINOLIN 5 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[2 [2 (DIETHYLAMINO)ETHYL] 6 OXO 2,6 DIHYDROINDAZOLO[4,3 GH]ISOQUINOLIN 5 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[2 [2 (DIMETHYLAMINO)ETHYL] 6 OXO 2,6 DIHYDROINDAZOLO[3,4 FG]ISOQUINOLIN 5 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[2 [2 (DIMETHYLAMINO)ETHYL] 6 OXO 2,6 DIHYDROINDAZOLO[4,3 GH]ISOQUINOLIN 5 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[2 [3 (DIMETHYLAMINO)PROPYL] 6 OXO 2,6 DIHYDROINDAZOLO[3,4 FG]ISOQUINOLIN 5 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[2 [3 (DIMETHYLAMINO)PROPYL] 6 OXO 2,6 DIHYDROINDAZOLO[4,3 GH]ISOQUINOLIN 5 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[6 [2 (1 PYRROLIDINYL)ETHYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[6 [2 (DIETHYLAMINO)ETHYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[6 [2 (DIMETHYLAMINO)ETHYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[6 [3 (DIETHYLAMINO)PROPYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[6 [3 (DIMETHYLAMINO)PROPYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[9 [2 (DIETHYLAMINO)ETHYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[9 [2 (DIMETHYLAMINO)ETHYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; 1,9 BIS[9 [3 (DIMETHYLAMINO)PROPYLAMINO] 5,10 DIOXO 5,10 DIHYDROBENZO[G]ISOQUINOLINE 9 YL] 5 METHYL 1,5,9 TRIAZANONANE; ANTHRACENE DERIVATIVE; ANTINEOPLASTIC AGENT; DIMER; INTERCALATING AGENT; MONOMER; PIXANTRONE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL CULTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG POTENCY; DRUG SYNTHESIS; FLUOROMETRY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE;

ANTHRACENES; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZA COMPOUNDS; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION PROFILING; HT29 CELLS; HUMANS; PYRAZOLES; RNA, MESSENGER;

EID: 39749159708     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7013937     Document Type: Article

References (38)