Solid-state NMR analysis comparing the designer-made antibiotic MSI-103 with its parent peptide PGLa in lipid bilayers

Biochemistry

Volumn 47, Issue 8, 2008, Pages 2601-2616

  Strandberg, Erik ^a   Kanithasen, Nathalie ^b   Tiltak, Deniz ^b   Bürck, Jochen ^a   Wadhwani, Parvesh ^a   Zwernemann, Olaf ^a   Ulrich, Anne S ^a,b  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARALLEL DIMERS; HEMOLYTIC ACTIVITIES;

DIMERS; LIPID BILAYERS; NUCLEAR MAGNETIC RESONANCE; PEPTIDES; SOLID STATE REACTIONS;

ANTIBIOTICS;

ALANINE; AMIDE; ANTIBIOTIC AGENT; DIMYRISTOYLPHOSPHATIDYLCHOLINE; MSI 103; PEPTIDYLGLYCYLLEUCINE CARBOXYAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; DIMERIZATION; DRUG DESIGN; DRUG SYNTHESIS; HEMOLYSIS; HYDROPHOBICITY; LIPID BILAYER; LIQUID CRYSTAL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SOLID STATE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CIRCULAR DICHROISM; DESIGNER DRUGS; DIMERIZATION; LIPID BILAYERS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OSMOLAR CONCENTRATION; PROTEIN CONFORMATION; PROTEIN PRECURSORS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

XENOPUS LAEVIS;

EID: 39749155818     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701944r     Document Type: Article

References (55)