Development of multivalent radioimmunonanoparticles for cancer imaging and therapy

Cancer Biotherapy and Radiopharmaceuticals

Volumn 23, Issue 1, 2008, Pages 82-91

  Natarajan, Arutselvan ^a,b   Xiong, Cheng Yi ^a   Gruettner, Cordula ^c   DeNardo, Gerald L ^a   DeNardo, Sally J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Molecular Cancer Institute   (United States)

^c MICROMOD PARTIKELTECHNOLOGIE GMBH   (Germany)

Author keywords

di scFv c; Immunoreactivity; Maleimide functionalization; MUC 1; Nanoparticle; Site specific conjugation

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID IN 131; DEXTRAN; MACROGOL; MALEIMIDE; MUCIN 1; MUCIN 1 ANTIBODY; PROTEIN ANTIBODY; RADIOPHARMACEUTICAL AGENT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; CHELATION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; ELECTROPHORESIS; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPERTHERMIA; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITY CONTROL; RADIOIMMUNOTHERAPY;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CA-15-3 ANTIGEN; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; FERRIC COMPOUNDS; HEAT; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INDIUM RADIOISOTOPES; MAGNETICS; MALEIMIDES; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; NEOPLASMS; RADIOIMMUNODETECTION; RADIOIMMUNOTHERAPY; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 39749145048     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2007.0410     Document Type: Article

References (28)