A low-toxic and efficient gene vector: Carboxymethyl dextran-graft- polyethylenimine

Journal of Biomedical Materials Research - Part A

Volumn 84, Issue 4, 2008, Pages 1102-1110

  Sun, Yun Xia ^a   Zhang, Xian Zheng ^a   Cheng, Han ^a   Cheng, Si Xue ^a   Zhuo, Ren Xi ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Carboxymethyl dextran; Gene vector; Polyethylenimine; Polyion complex

Indexed keywords

BIOCOMPATIBILITY; COMPLEXATION; DNA; ELECTROPHORESIS; GENES; MOLECULAR WEIGHT;

CARBOXYMETHYL DEXTRAN; GENE VECTORS; POLYETHYLENIMINE; POLYION COMPLEXES;

GRAFT COPOLYMERS;

AGAROSE; CARBOXYMETHYLDEXTRAN; GREEN FLUORESCENT PROTEIN; LUCIFERASE; PLASMID DNA; POLYETHYLENEIMINE;

ANIMAL CELL; ARTICLE; CELL DISRUPTION; CELL STRAIN 3T3; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; GEL ELECTROPHORESIS; GENE VECTOR; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN DETERMINATION; SYNTHESIS;

ANIMALS; CELL LINE; DEXTRANS; DNA; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES; MICE; MOLECULAR WEIGHT; NIH 3T3 CELLS; POLYETHYLENEIMINE; POLYMERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSFECTION;

EID: 39749138001     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31520     Document Type: Article

References (25)

1. Azzam T, Raskin A, Makovitzki A, Brem H, Vierling P, Lineal M, Domb AJ. Cationic polysaccharides for gene delivery. Macromolecules 2002;35:9947-9953.
2. Tseng WC, Jong CM. Improved stability of polycationic vector by dextran-grafted branched polyethylenimine. Biomacromolecules 2003;4:1277-1284.
3. Wong K, Sun G, Zhang X, Dai H, Liu Y, He C, Leong KW. PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjugate Chem 2006;17:152-158.
4. Forrest LM, Koerber JT, Pack DW. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. Bioconjugate Chem 2003;14:934-940.
5. Lungwitz U, Breunig M, Blunk T, Göpferich A. Polyethylenimine-based non-viral gene delivery systems. Eur J Pharm Biopharm 2005;60:247-266.
6. Fayazpour F, Lucas B, Alvarez-Lorenzo C, Sanders NN, Demeester J, DeSmedt SC. Physicochemical and transfection properties of cationic hydroxyl-ethylcellulose/DNA nanoparticles. Biomacromolecules 2006;7:2856-2862.
7. Wang Y, Chen P, Shen J. The development and characterization of a glutathione-sensitive cross-linked polyethylenimine gene vector. Biomaterials 2006;27:5292-5298.
8. Itaka K, Yamauchi K, Harada A, Nakamura K, Kawaguchi H, Kataoka K. Polyion complex micelles from plasmid DNA and poly(ethyleneglycol)-poly( L-lysine) block copolymer as serum-tolerable polyplex system: Physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials 2003;24:4495-4506.
9. Zhong Z, Feijen J. Low molecular weight linear polyethylenimine-b-poly(ethyleneglycol)-b-polyethylenimine triblock copolymers: Synthesis, characterization, and in vitro gene transfer properties. Biomacromolecules 2005;6:3440-3448.
10. Huang H, Tang G, Wang Q, Li D, Shen F, Zhou J, Yu H. Two novel non-viral gene delivery vectors: Low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin. Chem Commun 2006;2382-2384.
11. Azzam T, Eliyahu H, Shapira L, Linial M, Barenholz Y, Domb AJ. Polysaccharide-oligoamine based conjugates for gene delivery. J Med Chem 2002;45:1817-1824.
12. Yudovin-Farber I, Yanay C, Azzam T, Linial M, Domb AJ. Quaternary ammonium polysaccharides for gene delivery. Bioconjugate Chem 2005;16:1196-1203.
13. Kumashiro Y, Huh KM, Ooya T, Yui N. Modulatory factors on temperature-synchronized degradation of dextran grafted with thermoresponsive polymers and their hydrogels. Biomacromolecules 2001;2:874-879.
14. Cai Q, Wan Y, Bei J, Wang S. Synthesis and characterization of biodegradable polylactide-grafted dextran and its application as compatilizer. Biomaterials 2003;24:3555-3562.
15. Wagner K, Kautz A, Roder M, Schwalbe M, Pachmann K, Clement JH, Schnabelrauch M. Synthesis of oligonucleotide-functionalized magnetic nanoparticles and study on their in vitro cell uptake. Appl Organomet Chem 2004;18:514-519.
16. Huh KM, Hashi J, Ooya T, Yui N. Synthesis and characterization of dextran grafted with poly(N-isopropylacrylamide- co-N,N-dimethylacrylamide). Macromol Chem Phys 2000;201:613-619.
17. McLean KM, Johnson G, Chatelier RC, Beumer GJ, Steele JG, Griesser Hans J. Method of immobilization of carboxymethyl-dextran affects resistance to tissue and cell colonization. Colloids Surf B 2000;18:221-234.
18. Benns JM, Choi JS, Mahato RI, Park JS, Kim SW. pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft- poly(L-lysine) comb shaped polymer. Bioconjugate Chem 2000;11:637-645.
19. Benns JM, Mahato RI, Kim SW. Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J Controlled Release 2002;79:255-269.
20. Park MR, Han KO, Han IK, Cho MH, Nah JW, Choi YJ, Cho CS. Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. J Controlled Release 2005;105:367-380.
21. Petersen H, Kunath K, Martin AL, Stolnik S, Roberts CJ, Davies MC, Kissel T. Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines. Biomacromolecules 2002;3:926-936.
22. Choi JS, Lee EJ, Jang HS Park IS. New cationic liposomes for gene transfer into mammalian cells with high efficiency and low toxicity. Bioconjugate Chem 2001;12:108-113.
23. Wu D, Liu Y, Jiang X, He C, Goh SH, Leong KW. Hyperbranched poly (amino ester)s with different terminal amine groups for DNA delivery. Biomacromolecules 2006;7:1879-1883.
24. Pun SH, Bellocq NC, Liu A, Jensen G, Machemer T, Quijano E, Schluep T, Wen S, Engler H, Heidel J, Davis ME. Cyclo-dextrin-modified polyethylenimine polymers for gene delivery. Bioconjugate Chem 2004;15:831-840.
25. Kim T, Seo HJ, Choi JS, Jang HS, Baek J, Kim K, Park JS. PAMAM-PEG-PAMAM: Novel triblock copolymer as a biocompatible and efficient gene delivery carrier. Biomacromolecules 2004;5:2487-2492.