Telomere attrition and chromosome instability via downregulation of TRF2 contributes to arsenic trioxide-induced apoptosis of human T-cell leukemia cell line molt-4 cells

Cancer Biology and Therapy

Volumn 6, Issue 8, 2007, Pages 1197-1203

  Jiao, Yangwen ^c   Zhang, Weifang ^c   Liu, Junqing ^a   Ni, Wanmao ^a,c   Xu, Weilai ^a   Jin, Jie ^a,c   Qian, Wenbin ^a,b,c  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c BEIJING HOSPITAL   (China)

Author keywords

Acute lymphocytic leukemia; Apoptosis; Arsenic trioxide; hTERT; Telomerase; Telomere; TRF2

Indexed keywords

ARSENIC TRIOXIDE; MESSENGER RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERIC REPEAT BINDING FACTOR 2; ANTINEOPLASTIC AGENT; CASPASE; ORGANOARSENIC DERIVATIVE; OXIDE; TERT PROTEIN, HUMAN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DIVISION; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; T CELL LEUKEMIA; TELOMERE; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; T CELL LEUKEMIA LYMPHOMA; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; OXIDES; TELOMERASE; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2;

EID: 39749123314     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.8.4381     Document Type: Article

References (57)