Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 948-956

  Evans, Gary B ^a   Furneaux, Richard H ^a   Greatrex, Ben ^a   Murkin, Andrew S ^b   Schramm, Vern L ^b   Tyler, Peter C ^a  

^a CALLAGHAN INNOVATION   (New Zealand)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; AMINE; AZETIDINE DERIVATIVE; FORODESINE; HYDROLASE; METHYLTHIOADENOSINE NUCLEOSIDASE; N HYDROSYL HYDROLASE; N RIBOSYL PHOSPHORYLASE; PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY;

ANIMALS; AZETIDINES; CATTLE; HUMANS; PLASMODIUM FALCIPARUM; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39749114381     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701265n     Document Type: Article

References (54)