Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 852-860

  Clemente, José C ^a   Robbins, Arthur ^a   Graña, Paula ^b   Paleo, M Rita ^b   Correa, Juan F ^b   Villaverde, M Carmen ^b   Sardina, F Javier ^b   Govindasamy, Lakshmanan ^a   Agbandje McKenna, Mavis ^a   McKenna, Robert ^a   Dunn, Ben M ^a   Sussman, Fredy ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CGP 53820; CYCLOHEXANE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DRUG CONFORMATION; DRUG DESIGN; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; GENE MUTATION; MOLECULAR DYNAMICS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; STEREOISOMERISM; THERMODYNAMICS;

EID: 39749109358     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701170f     Document Type: Article

References (42)