Real-time assessment of granule and tablet properties using in-line data from a high-shear granulation process

Journal of Pharmaceutical Sciences

Volumn 97, Issue 2, 2008, Pages 950-959

  Luukkonen, Pirjo ^a   Fransson, Magnus ^a   Björn, Ingela Niklasson ^a   Hautala, Jaana ^b   Lagerholm, Bengt ^a   Folestad, Staffan ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Granulation; NIR; Particle size; PAT control; Physical characterization; Power consumption; Process data; Tableting; Temperature

Indexed keywords

EMCOCEL 50; MANNITOL; MICROCRYSTALLINE CELLULOSE; PLASDONE K 29 32; POVIDONE; UNCLASSIFIED DRUG; WATER;

ARTICLE; DRUG GRANULATION; DRUG GRANULE; FACTORIAL DESIGN; IMPELLER; NEAR INFRARED REFLECTANCE SPECTROSCOPY; PARTICLE SIZE; PROCESS TECHNOLOGY; TABLET FORMULATION; TABLET HARDNESS; TABLET POROSITY; TABLET PROPERTY; TEMPERATURE;

EID: 39749101853     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20998     Document Type: Article

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