Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 3, 2008, Pages 794-802

  De Ross, J ^a   Castilho, V M ^a   Brandão, M L ^a   Nobre, M J ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anxiety; Diazepam withdrawal; Elevated plus maze; Prepulse inhibition; Ultrasonic vocalization

Indexed keywords

DIAZEPAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; FOOTSHOCK; MALE; MAZE TEST; MOTOR PERFORMANCE; NONHUMAN; POST HOC ANALYSIS; PREPULSE INHIBITION; RAT; SENSORIMOTOR FUNCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; DIAZEPAM; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION ROUTES; ELECTROSHOCK; EMOTIONS; INHIBITION (PSYCHOLOGY); MALE; MAZE LEARNING; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME; VOCALIZATION, ANIMAL;

EID: 39749100000     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2007.12.013     Document Type: Article

References (72)

1. Abduljawad K.A., Langley R.W., Bradshaw C.M., and Szabadi E. Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by prepulses' in man. J Psychopharmacol 11 (1997) 29-34
2. Acri J.B. Nicotine modulates effects of stress on acoustic startle reflexes in rats: dependence on dose, stressor and initial reactivity. Psychopharmacology (Berl) 116 (1994) 255-265
3. Anseloni V.Z., and Brandão M.L. Ethopharmacological analysis of behaviour of rats using variations of the elevated plus-maze. Behav Pharmacol 8 (1997) 533-540
4. Ashton H. The diagnosis and management of benzodiazepine dependence. Curr Opin Psychiatry 18 (2005) 249-255
5. Bassi G.S., Nobre M.J., Carvalho M.C., and Brandão M.L. Substance P injected into the dorsal periaqueductal gray causes anxiogenic effects similar to the long-term isolation as assessed by ultrasound vocalizations measurements. Behav Brain Res 182 (2007) 301-307
6. Begg D.P., Hallam K.T., and Norman T.R. Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists. Behav Brain Res 161 (2005) 286-290
7. Blanchard R.J., Blanchard D.C., Agullana R., and Weiss S.M. Twenty-two KHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems. Physiol Behav 50 (1991) 967-972
8. Brandão M.L., Troncoso A.C., de Souza Silva A., and Huston J.P. The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations. Eur J Pharmacol 463 (2003) 225-233
9. Brandão M.L., Borelli K.G., Nobre M.J., Santos J.M., Albrechet-Souza L., Oliveira A.R., et al. Gabaergic regulation of the neural organization of fear in the midbrain tectum. Neurosci Biobehav Rev 29 (2005) 1299-1311
10. Brudzynski S.M., and Chiu E.M. Behavioural responses of laboratory rats to playback of 22 KHz ultrasonic calls. Physiol Behav 57 (1995) 1039-1044
11. Bubser M., and Koch M. Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex. Psychopharmacology (Berl) 113 (1994) 487-492
12. Busto U., Sellers E.M., Naranjo C.A., Cappell H.D., Sanchez-Craig M., and Simpkins J. Patterns of benzodiazepine abuse and dependence. Br J Addict 81 (1986) 87-94
13. Busto U.E., and Sellers E.M. Anxiolytics and sedative/hypnotics dependence. Br J Addict 86 (1991) 1647-1652
14. Cabral A., Isoardi N., Salum C., Macedo C.E., Nobre M.J., Brandão M.L., et al. Fear state induced by ethanol withdrawal may be due to the sensitization of the neural substrates of aversion in the dPAG. Exp Neurol 200 (2006) 200-208
15. Chester J.A., Blose A.M., and Froehlich J.C. Acoustic startle reactivity during acute alcohol withdrawal in rats that differ in genetic predisposition toward alcohol drinking: effect of stimulus characteristics. Alcohol Clin Exp Res 28 (2004) 677-687
16. Chugh Y., Saha N., Sankaranarayanan A., and Sharma P.L. Effect of peripheral administration of cinnarizine and verapamil on the abstinence syndrome in diazepam-dependent rats. Psychopharmacology (Berl) 106 (1992) 127-130
17. Cuomo V., Cagiano R., De Salvia M.A., Maselli M.A., Renna G., and Racagni G. Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines. Life Sci 43 (1988) 485-491
18. Davis M., and Gendelman P.M. Plasticity of the acoustic startle response in the acutely decerebrate rat. J Comp Physiol Psychol 91 (1997) 549-563
19. De Vry J., Benz U., Schreiber R., and Traber J. Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs. Eur J Pharmacol 249 (1993) 331-339
20. DelPezzo E.M., and Hoffman H.S. Attentional factors in the inhibition of a reflex by a visual stimulus. Science 210 (1980) 673-674
21. Emmett-Oglesby M.W., Spencer Jr. D.G., Lewis M., Elmesallamy F., and Lal H. Anxiogenic aspects of diazepam withdrawal can be detected in animals. Eur J Pharmacol 92 (1983) 127-130
22. Emmett-Oglesby M.W., Spencer Jr. D.G., Elmesallamy F., and Lal H. The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats. Life Sci 33 (1983) 161-168
23. Fendt M., and Mucha R.F. Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe for drug-related motivational states. Psychopharmacology (Berl) 155 (2001) 242-250
24. File S.E. The history of benzodiazepine dependence: a review of animal studies. Neurosci Biobehav Rev 14 (1990) 135-146
25. File S.E., and Andrews N. Low but not high doses of buspirone reduce the anxiogenic effects of diazepam withdrawal. Psychopharmacology (Berl) 105 (1991) 578-582
26. Filion D.L., and Cirrani M. The function significance of prepulse inhibition: a test of the protection of processing theory. Psychophysiology 31 (1994) S46
27. Fontanesi L.B., Ferreira R., Cabral A., Castilho V.M., Brandão M.L., and Nobre M.J. Brainstem areas activated by diazepam withdrawal as measured by Fos-protein immunoreactivity in rats. Brain Res 1166 (2007) 35-46
28. Geyer M.A., and Ellenbroek B. Animal behavior models of the mechanisms underlying antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry 27 (2003) 1071-1079
29. Graham F.K., Putnam L.E., and Leavitt L.A. Lead-stimulation effects on human cardiac orienting and blink reflexes. J Exp Psychol 104 (1975) 161-169
30. Greenblatt D.J., and Shader R.I. Drug therapy. Benzodiazepines (second of two parts). N Engl J Med 291 (1974) 1239-1243
31. Griebel G., Moreau J.L., Jenck F., Misslin R., and Martin J.R. Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents. Psychopharmacology (Berl) 113 (1994) 463-470
32. Hackley S.A., and Graham F.K. Effects of attending selectively to the spatial position of reflex-eliciting and reflex-modulating stimuli. J Exp Psychol Hum Percept Perform 13 (1987) 411-424
33. Hackley S.A., Woldorff M., and Hillyard S.A. Combined use of microreflexes and event-related brain potentials as measures of auditory selective attention. Psychophysiology 24 (1987) 632-647
34. Harris A.C., and Gewirtz J.C. Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety. Psychopharmacology (Berl) 171 (2004) 140-147
35. Helton D.R., Modlin D.L., Tizzano J.P., and Rasmussen K. Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity. Psychopharmacology (Berl) 113 (1993) 205-210
36. Hoffman H.S., and Ison J.R. Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input. Psychol Rev 87 (1980) 175-189
37. Izzo E., Auta J., Impagnatiello F., Pesold C., Guidotti A., and Costa E. Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines. Proc Natl Acad Sci USA 98 (2001) 3483-3488
38. Kalinichev M., and Holtzman S.G. Changes in urination/defecation, auditory startle response, and startle-induced ultrasonic vocalizations in rats undergoing morphine withdrawal: similarities and differences between acute and chronic dependence. J Pharmacol Exp Ther 304 (2003) 603-609
39. Kikusui T., Takeuchi Y., and Mori Y. Pharmacological manipulations of the extinction process of fear-induced ultrasonic vocalization in rats. J Vet Med Sci 63 (2001) 591-595
40. Koch M., and Bubser M. Deficient sensorimotor gating after 6-hydroxydopamine lesion of the rat medial prefrontal cortex is reversed by haloperidol. Eur J Neurosci 6 (1994) 1837-1845
41. Koch M. The neurobiology of startle. Prog Neurobiol 59 (1999) 107-128
42. Lacerra C., Martijena I.D., Bustos S.G., and Molina V.A. Benzodiazepine withdrawal facilitates the subsequent onset of escape failures and anhedonia: influence of different antidepressant drugs. Brain Res 819 (1999) 40-47
43. Ladewig D. Dependence liability of the benzodiazepines. Drug Alcohol Depend 13 (1984) 139-149
44. Lee Y., Lopez D.E., Meloni E.G., and Davis M. A primary acoustic startle pathway: obligatory role of cochlear root neurons and the nucleus reticularis pontis caudalis. J Neurosci 16 (1996) 3775-3789
45. Leitner D.S., and Cohen M.E. Role of the inferior colliculus in the inhibition of acoustic startle in the rat. Physiol Behav 34 (1985) 65-70
46. Li L., and Shao F. Impaired auditory sensorimotor gating: an animal model of schizophrenia. Chin Sci Bull 48 (2003) 2031-2037
47. Lukas S.E., and Griffiths R.R. Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam. Science 217 (1982) 1161-1163
48. Markou A., Kosten T.R., and Koob G.F. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 18 (1998) 135-174
49. Marks J. The Benzodiazepines: use, oversuse, misuse, abuse. 2nd ed. (1978), MTP Press, Lancaster
50. Martijena I.D., Tapia M., and Molina V.A. Altered behavioral and neurochemical response to stress in benzodiazepine-withdrawn rats. Brain Res 712 (1996) 239-244
51. Miczek K.A., and Vivian J.A. Automatic quantification of withdrawal from 5-day diazepam in rats: ultrasonic distress vocalizations and hyperreflexia to acoustic startle stimuli. Psychopharmacology (Berl) 110 (1993) 379-382
52. Mussat-Whitlow B.J., and Blumenthal T.D. Impact of acoustic and vibro-tactile prepulse on acoustic and electrical blink reflexes: startle inhibition and task accuracy results. Psychophysiology 34 (1997) S66
53. Nielsen C.K., and Sanchez C. Effect of chronic diazepam treatment on foot-shock-induced ultrasonic vocalization in adult male rats. Pharmacol Toxicol 77 (1995) 177-181
54. Nobre M.J., and Brandão M.L. Analysis of freezing behavior and ultrasonic vocalization in response to foot-shocks, ultrasound signals and GABAergic inhibition in the inferior colliculus: effects of muscimol and midazolam. Eur Neuropsychopharmacol 14 (2004) 45-52
55. Nobre M., Sandner G., and Brandão M.L. Enhancement of acoustic evoked potentials and impairment of startle reflex induced by reduction of GABAergic control of the neural substrates of aversion in the inferior colliculus. Hear Res 184 (2003) 82-90
56. Norris C.M., and Blumenthal T.D. Evidence for the protection of preattentive processing during inhibition of the acoustic startle response. Psychophysiology 32 (1995) S57
57. Nunes Mamede Rosa M.L., Nobre M.J., Ribeiro O.A., and Brandão M.L. Isolation-induced changes in ultrasonic vocalization, fear-potentiated startle and prepulse inhibition in rats. Neuropsychobiology 51 (2005) 248-255
58. Owen R.T., and Tyrer P. Benzodiazepine dependence. A review of the evidence. Drugs 25 (1983) 385-398
59. Peleg-Raibstein D., Sydekum E., Russig H., and Feldon J. Withdrawal from continuous amphetamine administration abolishes latent inhibition but leaves prepulse inhibition intact. Psychopharmacology (Berl) 185 (2006) 226-239
60. Pellow S., and File S.E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24 (1986) 525-529
61. Petursson H., and Lader M.H. Benzodiazepine dependence. Br J Addict 76 (1981) 133-145
62. Petursson H., and Lader M.H. Withdrawal from long-term benzodiazepine treatment. Br Med J (Clin Res Ed) 283 (1981) 643-645
63. Pohorecky L.A., Cagan M., Brick J., and Jaffe S.L. The startle response in rats: effect of ethanol. Pharmacol Biochem Behav 4 (1976) 311-316
64. Rasmussen K., Helton D.R., Berger J.E., and Scearce E. The CCK-B antagonist LY288513 blocks effects of diazepam withdrawal on auditory startle. Neuroreport 5 (1993) 154-156
65. Rosebush P.I., and Mazurek M.F. Catatonia after benzodiazepine withdrawal. J Clin Psychopharmacol 16 (1996) 315-319
66. Silverstein L.D., Graham F.K., and Calloway J.M. Preconditioning and excitability of the human orbicularis oculi reflex as a function of state. Electroencephalogr Clin Neurophysiol 48 (1980) 406-417
67. Swerdlow N.R., Geyer M.A., and Braff D.L. Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) 156 (2001) 194-215
68. Swerdlow N.R., Lipska B.K., Weinberger D.R., Braff D.L., Jaskiw G.E., and Geyer M.A. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology (Berl) 122 (1995) 27-34
69. Vivian J.A., Farrell W.J., Sapperstein S.B., and Miczek K.A. Diazepam withdrawal: effects of diazepam and gepirone on acoustic startle-induced 22 KHz ultrasonic vocalizations. Psychopharmacology (Berl) 114 (1994) 101-108
70. Vivian J.A., and Miczek K.A. Diazepam and gepirone selectively attenuate either 20-32 or 32-64 KHz ultrasonic vocalizations during aggressive encounters. Psychopharmacology (Berl) 112 (1993) 66-73
71. Woods J.H., Katz J.L., and Winger G. Abuse liability of benzodiazepines. Pharmacol Rev 39 (1987) 251-413
72. Zou D., Huang J., Wu X., and Li L. Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats. Neuropharmacology 52 (2007) 476-486