Comment and reply: A double-blind study evaluating the long-term safety of varenicline for smoking cessation

Current Medical Research and Opinion

Volumn 24, Issue 2, 2008, Pages 577-579

  Spangler, John G ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; NICOTINE; PLACEBO; VARENICLINE;

CARDIOTOXICITY; CATARACT; CATARACTOGENESIS; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; HUMAN; KIDNEY DYSFUNCTION; LETTER; NICOTINE REPLACEMENT THERAPY; OXIDATIVE STRESS; PREGNANCY; SMOKING CESSATION; TOBACCO DEPENDENCE;

EID: 39749092412     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079908X261140     Document Type: Letter

References (13)

1. Fiore MD, Bailey WC, Cohen SJ, et al. Clinical Practice Guideline: Treating Tobacco Use and Dependence. Washington DC, US Public Health Service, 2000
2. Tonstad S, Tonnesen P, Hajek P, et al. Varenicline Phase 3 Study Group. Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial. JAMA 2006;296:64-71
3. Jorenby DE, Hays JT, Rigotti NA, et al. Varenicline Phase 3 Study Group. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 2006;296:56-63
4. Pfizer. Chantix Package Insert. Available from: http://www.pfizer.com/ pfizer/download/uspi_chantix.pdf [Last accessed: 14 November 2007]
5. Williams KE, Reeves KR, Billing CB Jr, et al. A double-blind study evaluating the long-term safety of varenicline for smoking cessation. Curr Med Res Opin 2007;23:793-801
6. Weintraub JM, Willett WC, Rosner B, et al. Smoking cessation and risk of cataract extraction among US women and men. Am J Epidemiol 2002;155:72-9
7. Barnoya J, Glantz SA. Cardiovascular effects of second hand smoke: Nearly as large as smoking. Circulation 2005;111:2684-98
8. Hankinson SE, Willett WC, Colditz GA, et al. A prospective study of cigarette smoking and risk of cataract surgery in women. JAMA 1992;268:994-8
9. Klein BE, Klein R, Linton KL, Franke T. Cigarette smoking and lens opacities: the Beaver Dam Eye Study. Am J Prev Med 1993;9(1):27-30
10. Kovacic P. Mechanism of varenicline (clinical ramifications): electron transfer and oxidative stress. Med Hypoth 2007;68:1184-5
11. Obach RS, Reed-Hagen AE, Kruger SS, et al. Metabolism and disposition of varenicline, a selective α4β2 acetyl choline receptor partial agonist, in vivo and in vitro. Drug Metab Dispos 2006;34:121-30
12. Wang J, Wang X, Irnaten M, et al. Endogenous acetylcholine and nicotine activation enhances GABAergic and glycinergic inputs to cardiac vagal neurons. J Neurophysiol 2003;89(5):2473-81
13. Wadman M. Experts call for active surveillance of drug safety. Nature 2007;22:358-9