Antioxidant UPF1 attenuates myocardial stunning in isolated rat hearts

International Journal of Cardiology

Volumn 125, Issue 1, 2008, Pages 133-135

  Kals, Jaak ^a   Starkopf, Joel ^a   Zilmer, Mihkel ^a   Pruler, Tõnis ^a   Pulges, Kristel ^a   Hallaste, Monika ^a   Kals, Mart ^a   Pulges, Andres ^a,b   Soomets, Ursel ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b North Estonian Regional Hospital   (Estonia)

Author keywords

Antioxidants; Cardioprotection; Glutathione; Ischaemia reperfusion injury; Rat heart

Indexed keywords

4 METHOXY TYROSINYL GAMMA GLUTAMYL CYSTEINYL GLYCINE; ANTIOXIDANT; GLUTATHIONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STUNNED HEART MUSCLE;

EID: 39749091763     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2007.01.032     Document Type: Article

References (12)

1. R. Bolli E. Marban Molecular and cellular mechanisms of myocardial stunning Physiol Rev 79 1999 609 634
2. A.L. Moens M.J. Claeys J.P. Timmermans C.J. Vrints Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process Int J Cardiol 100 2005 179 190
3. M. Zilmer U. Soomets A. Rehema U. Langel The glutathione system as an attractive therapeutic target Drug Des Rev Online 2 2005 121 127
4. F. Gao C.L. Yao E. Gao Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury J Pharmacol Exp Ther 301 2002 543 550
5. J.B. Schulz J. Lindenau J. Seyfried J. Dichgans Glutathione, oxidative stress and neurodegeneration Eur J Biochem 267 2000 4904 4911
6. P. Põder M. Zilmer J. Starkopf An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia Neurosci Lett 370 2004 45 50
7. U. Soomets M. Zilmer Ü. Langel Manual solid-phase synthesis of glutathione analogs: a laboratory-based short course Methods Mol Biol 298 2005 241 257
8. G. Wu Y.Z. Fang S. Yang J.R. Lupton N.D. Turner Glutathione metabolism and its implications for health J Nutr 134 2004 489 492
9. A. Pastore G. Federici E. Bertini Analysis of glutathione: implication in redox and detoxification Clin Chim Acta 333 2003 19 39
10. F.Q. Schafer G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic Biol Med 30 2001 1191 1212
11. H.H. Klein S. Pich P. Schuff-Werner P. Niedmann U. Blattmann K. Nebendahl The effects of Trolox, a water-soluble vitamin E analogue, in regionally ischemic, reperfused porcine hearts Int J Cardiol 32 1991 291 301
12. E. Karelson R. Mahlapuu M. Zilmer U. Soomets N. Bogdanovic U. Langel Possible signaling by glutathione and its novel analogue through potent stimulation of fontocortical G proteins in normal aging and in Alzheimer's disease Ann N Y Acad Sci 973 2002 537 540