Reproductive and developmental toxicity screening test of tetrahydrofurfuryl alcohol in rats

Reproductive Toxicology

Volumn 25, Issue 2, 2008, Pages 231-238

  Hirata Koizumi, Mutsuko ^a   Noda, Atsushi ^b   Hirose, Akihiko ^a   Kamata, Eiichi ^a   Ema, Makoto ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Res Inst Anim Sci Biochem T   (Japan)

Author keywords

Postimplantation loss; Postnatal loss; Rat; Reproductive and developmental toxicity; Testicular toxicity; Tetrahydrofurfuryl alcohol

Indexed keywords

ALCOHOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; COPULATION; DEVELOPMENTAL DISORDER; EPIDIDYMIS; FEMALE; FERTILITY; GESTATION PERIOD; HISTOPATHOLOGY; IMPLANTATION; LACTATION; LOCOMOTION; MALE; MATING; NEWBORN; NIDATION; NONHUMAN; PREGNANCY; RAT; REPRODUCTIVE TOXICITY; SCREENING TEST; SEX RATIO; SPLEEN; TESTIS; THYMUS; WEIGHT GAIN;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRUS; FEMALE; FETUS; FURANS; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; WEIGHT GAIN;

RATTUS;

EID: 39749083473     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2007.11.006     Document Type: Article

References (25)

1. OECD (Organisation for Economic Co-operation and Development). 2-Furanmethanol, tetrahydro-. SIDS documents for SIAM 20, April 19-21, 2005. Available at: http://cs3-hq.oecd.org/scripts/hpv/, accessed on August 8, 2007.
2. METI (Ministry of Economy, Trade and Industry, Japan). Research results on the actual production and import volume of chemicals in 2004 (in Japanese). Available at: http://www.meti.go.jp/policy/chemical_management/kasinhou/jittaichousa/kakuhouchi18.pdf, accessed on August 8, 2007.
3. Penn Specialty Chemicals, Inc. Technical Bulletin of Tetrahydrofurfuryl alcohol. 2005. Available at: http://www.pschem.com/pdfs/thfabulletin4.pdf, accessed on August 8, 2007.
4. Allen LVJr.. Compounding topical dosage forms: ointments, creams, pastes and lotions. Secundum Artem-current & practical compounding information for the pharmacist, Vol. 3, No. 2. Minnesota: Paddock Laboratories, Inc. Available at: http://www.paddocklabs.com/forms/secundum/volume_3_2.pdf, accessed on July 30, 2007.
5. MHLW (Ministry of Health, Labour and Welfare, Japan). Flavoring agents as food additives. 2003. Available at: http://www.jetro.go.jp/jpn/regulations/guidebook/pdf/free/flavor2003aug-e.pdf#search='Tetrahydrofurfuryl%20alcohol%209799-4', accessed on July 30, 2007.
6. FDA (Food and Drug Administration, USA). Synthetic flavoring substances and adjuvants. Code of Federal Regulations. Title 21, Vol.3, 21 CFR 172.515, lastly amended at 69 FR 24511, May 4, 2004.
7. EC (European Commission). Commission decision of 23 February 1999 adopting a register of flavouring substances used in or on foodstuffs drawn up in application of Regulation (EC) No. 2232/96 of the European Parliament and of the Council of 28 October 1996 (1999/217/EC). Official Journal of the European Communities. L 84:March 27;1999.
8. 2OH. In: Fassett D.W., and Irish D.D. (Eds). Industrial hygiene and toxicology Vol. 2 (1963), Interscience Publishers, Sydney 1491-1492
9. Coquet P.H., Durand G., Laillier J., and Plazonnet B. Evaluation of ocular irritation in the rabbit: objective versus subjective assessment. Toxicol Appl Pharmacol 39 (1977) 129-139
10. Lashmar U.T., Hadgraft J., and Thomas N. Topical application of penetration enhancers to the skin of nude mice: a histopathological study. J Pharm Pharmacol 41 (1989) 118-122
11. TSCA. A dose range-finding developmental toxicity study in rats with THFA. 8EHQ-1092-8576S; October 1992.
12. MHLW (Ministry of Health, Labour, Welfare, Japan). Tetrahydrofurfuryl alcohol. Toxicity testing reports of environmental chemicals Vol. 11 (2004), Chemicals Investigation Promoting Council, Tokyo p. 155-194
13. OECD (Organisation for Economic Co-operation and Development). Guideline 421, Reproduction/Developmental Toxicity Screening Test (adopted on July 27, 1995), OECD Guidelines for the Testing of Chemicals, section 5.
14. EPA (Environmental Protection Agency, USA). Hazard assessment for the tolerance reassessment of tetrahydrofurfuryl alcohol (THFA) (2006), Office of Prevention, Pesticides and Toxic Substances; February, 21
15. OECD (Organization for Economic Co-operation and Development). Principles on Good Laboratory Practice (revised in 1997). OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring. No. 1.
16. EA, MHW, MITI (Environment Agency, Ministry of Health and Welfare, Ministry of International Trade and Industry, Japan). Testing Facility Provided in the Article 4 in the Ordinance Prescribing Test Relating to New Chemical Substances and Toxicity Research of Designated Chemical Substances. Joint notification by Planning and Coordination Bureau, Environment Agency (Kanpogyo No. 39), Pharmaceutical Affairs Bureau, Ministry of Health and Welfare (Yakuhatsu No. 229) and Basic Industries Bureaus, Ministry of International Trade and Industry (Kikyoku No. 85), March 31, 1984, lastly amended on January 23-24, 2001.
17. Kandori H., Chatani F., and Miyajima H. Male reproductive organs. The Japanese society of toxicologic pathology editor Toxicologic Histopathology (in Japanese) (2000), International Press Editing Centre Incorporation, Tokyo p. 283-314
18. Parker R.M. Testing for reproductive toxicity. In: Hood R.D. (Ed). Developmental and reproductive toxicology-a practical approach (2006), CRC Press, Taylor & Fransis Group, Florida 425-487
19. Robaire B., Smith S., and Hales B.F. Suppression of spermatogenesis by testosterone in adult male rats: effect on fertility, pregnancy outcome and progeny. Biol Reprod 31 (1984) 221-230
20. Aafjes J.H., Vels J.M., and Schenck E. Fertility of rats with artificial oligozoospermia. J Reprod Fertil 58 (1980) 345-351
21. Wilson J.G. Methods for administering agents and detecting malformations in experimental animals. In: Wilson J.G., and Warkany J. (Eds). Teratology: principles and techniques (1965), The University of Chicago Press, Chicago 262-277
22. Kameyama Y, Tanimura T, Yasuda M, editors. Spontaneous malformations in laboratory animals-photographic atlas and reference data. Cong Anom 1980;20:25-106.
23. Morita H., Ariyuki F., Inomata N., Nishimura K., Hasegawa Y., Miyamoto M., et al. Spontaneous malformations in laboratory animals: frequency of external, internal and skeletal malformations in rats, rabbits and mice. Cong Anom 27 (1987) 147-206
24. Nakatsuka T., Horimoto M., Ito M., Matsubara Y., Akaike M., and Ariyuki F. Japan Pharmaceutical Manufacturers Association (JPMA) survey on background control data of developmental and reproductive toxicity studies in rats, rabbits and mice. Cong Anom 37 (1997) 47-138
25. Wilson J.G. Collection and interpretation of results. In: Wilson J.G. (Ed). Environment and birth defects vol. 1 (1973), Academic Press, New York 173-193