Production of the therapeutic radionuclides 193mPt and 195mPt with high specific activity via α-particle-induced reactions on 192Os

Applied Radiation and Isotopes

Volumn 66, Issue 4, 2008, Pages 545-551

  Hilgers, K ^a   Coenen, H H ^a   Qaim, S M ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Particle irradiation; Chemical separation; Cross section; Excitation function; High current irradiation; Internal radiotherapy; Osmium 192; Platinum 193m; Platinum 195m; Quality control

Indexed keywords

CHEMICAL SEPARATION; EXCITATION FUNCTIONS; INTERNAL RADIOTHERAPY; OSMIUM-192; PARTICLE IRRADIATION;

ELECTRODEPOSITION; METAL FOIL; PLATINUM; QUALITY CONTROL; RADIOTHERAPY; SEPARATION;

RADIOISOTOPES;

OSMIUM; OSMIUM 192; PLATINUM; PLATINUM 193M; PLATINUM 195M; UNCLASSIFIED DRUG;

ALPHA RADIATION; ARTICLE; CALCULATION; CHEMICAL REACTION; DRUG SYNTHESIS; ENERGY; PRIORITY JOURNAL; RADIATION DOSE; RADIOCHEMISTRY;

ALPHA PARTICLES; NUCLEAR MEDICINE; OSMIUM; PLATINUM; RADIOISOTOPES; RADIOPHARMACEUTICALS;

EID: 39649108623     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2007.10.009     Document Type: Article

References (18)

1. Akaboshi, M., 2003. Platinum 195 m: in manual for reactor produced radioisotopes. IAEA-TECDOC-1340, pp. 171-178.
2. 193mPt: radiotoxicity versus chemotoxicity of the antitumor drug in mammalian cells. In: Howell R.W., Narra V.R., Sastry K.S.R., and Rao D.V. (Eds). Biophysical Aspects of Auger Processes (1992), American Institute of Physics, Inc., Woodbury, NY 11797, USA 336-351
3. Bonardi M., Birattari C., Gallorini M., Groppi F., Arginelli D., and Gini L. Cyclotoron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies. J. Radioanal. Nucl. Chem. 236 (1998) 159-164
4. 4He,γ) reactions. Nucl. Phys. A 102 (1967) 161
5. Chakrabarty S., Tomar B.S., Goswani A., Raman V.A., and Manohar S.B. Preparation of thin osmium targets by electrodeposition. Nucl. Instrum. Methods B 174 (2001) 212-216
6. Fresenius W., and Jander G. Handbuch der analytischen Chemie, Zweiter Teil: qualitative Nachweisverfahren, Band VIII b β Elemente der achten Hauptgruppe, II (Platinmetalle) (1951), Springer OHG, Berlin, Göttingen, Heidelberg, Germany p. 172
7. Firestone R.B. Tables of Isotopes, CDROM-Edition, Version 1.0 (1996), Wiley-Interscience, New York
8. Groppi F., Birattari C., Bonardi M., Gallorini M., and Gini L. Thin target excitation functions for (α,xn) reactions on osmium targets for platinum radiotracer production. J. Radioanal. Nucl. Chem. 249 (2001) 289-293
9. 140Nd. Radiochim. Acta 93 (2005) 553-560
10. Hoefnagel C.A. Radionuclide therapy revisited. Eur. J. Nucl. Med. 18 (1991) 408-431
11. 195mPt-labelled antitumor drug, cis-dichlorodiammineplatinum(II), cis-DDP. Radiochim. Acta 31 (1982) 27-36
12. Mariani G., Bodei L., Adelstein S.J., and Kassis A.I. Emerging roles for radiometabolic therapy of tumors based on Auger electron emission. J. Nucl. Med. 41 (2000) 1519-1521
13. 73Se. Radiochim. Acta 50 (1990) 27-31
14. Qaim S.M. Target development for medical radioisotope production at a cyclotron. Nucl. Instrum. Methods A 282 (1989) 289-295
15. Qaim S.M. Therapeutic radionuclies and nuclear data. Radiochim. Acta 89 (2001) 297-302
16. Tárkányi, T.F., Gul, K., Hermanne, A., Mustafa, M.G., Nortier, F.M., Qaim, S.M., Scholten, B., Shubin, Yu., Takács, S., Zhuang, Y., 2001. Beam monitor reactions: in charged-particle cross section database for medical radioisotope production. IAEA-TECDOC-1211, pp. 49-152.
17. 191Pt, a radiolabel for the synthesis and biological investigations of platinum anti-tumor compounds. Radiochim. Acta 54 (1991) 29-34
18. Williamson, C.F., Boujot, J.P., Picard, J., 1966. Tables of range and stopping power of chemical elements for charged particles of energies from 0.5 to 500 MeV. Rapport CEA-R 3042.